Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158549 | 0.85 | MAP3K11 (0.50) | MAP3K11ADORA2AKDM4ERECQLHSD17B10 | |
| SCHEMBL4006573 | 0.82 | ATR (0.59) | — | |
| SCHEMBL3924773 | 0.82 | EGFR (0.48) | HRH3KDM4ERECQLHSD17B10 | |
| SCHEMBL4010236 | 0.81 | JAK2 (0.51) | MAP3K11KDM4ERECQLHSD17B10 | |
| SCHEMBL4139890 | 0.78 | KDM4E (0.50) | ADORA2AKDM4ERECQLHSD17B10 | |
| SCHEMBL4012928 | 0.77 | ATR (0.54) | MCHR1MAP3K11ADORA2AADORA1 | |
| SCHEMBL3927916 | 0.76 | ATR (0.48) | MCHR1MAP3K11ADORA2AADORA1 | |
| SCHEMBL4011105 | 0.76 | MCHR1 (0.52) | MCHR1HRH3LTA4HMAP3K11ADORA2A | |
| SCHEMBL220877 | 0.76 | NOS3 (0.61) | MCHR1HRH3LTA4HADORA2AADORA1 | |
| SCHEMBL4297778 | 0.76 | ATR (0.58) | MAP3K11ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |