Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158549 | 0.82 | MAP3K11 (0.50) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL3924773 | 0.82 | EGFR (0.48) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL4010236 | 0.81 | JAK2 (0.51) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL3928126 | 0.78 | MCHR1 (0.47) | KDM4EHSD17B10RECQLADORA2A | |
| SCHEMBL221219 | 0.71 | NOS1 (0.71) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1899791 | 0.70 | RPS6KB1 (0.51) | KDM4EALDH1A1TP53SMN1; SMN2MAPT | |
| SCHEMBL13613482 | 0.69 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL3987482 | 0.68 | KDM4E (0.52) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL3987496 | 0.68 | HPGD (0.58) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL4006573 | 0.67 | ATR (0.59) | EGFRATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |