Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648267 | 0.88 | ERN1 (0.37) | CASP6TSHRLMNACA1CA2 | |
| SCHEMBL4180845 | 0.80 | ALDH1A1 (0.42) | TSHRLMNA | |
| SCHEMBL3230116 | 0.79 | CA1 (0.43) | CASP6TSHRLMNACA1CA2 | |
| SCHEMBL14565984 | 0.78 | CASP6 (0.42) | CASP6TSHRLMNACA1CA2 | |
| SCHEMBL12104562 | 0.78 | TSHR (0.46) | CASP6TSHRLMNACA1CA2 | |
| SCHEMBL2680731 | 0.74 | CYP3A4 (0.39) | TSHRLMNAGPR35TDP1 | |
| SCHEMBL3541314 | 0.74 | TSHR (0.39) | CASP6TSHRLMNACA1CA2 | |
| SCHEMBL27731078 | 0.74 | CYP1A2 (0.44) | CASP6TSHRLMNAGPR35 | |
| SCHEMBL15878596 | 0.71 | GSK3B (0.61) | GPR35GSK3B | |
| SCHEMBL11458447 | 0.70 | CA1 (0.42) | CASP6TSHRLMNACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884066-B | 2, 3, 5-substituted thiophene compounds as protein kinase inhibitors | 韩国科学技术研究院 | 2021-08-24 | — | — | CN | disclosed |
| EP-3418275-B1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | KOREA INST SCI & TECH (KR) | 2021-03-17 | — | — | EP | disclosed |
| US-10442796-B2 | 2,3,5-substituted thiophene compound as protein kinase inhibitor | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-15 | — | — | US | disclosed |
| US-20190047993-A1 | Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-02-14 | — | — | US | disclosed |
| EP-3418275-A1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | Korea Institute of Science and Technology (KR) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142325-A1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | 한국과학기술연구원 | 2017-08-24 | — | — | WO | disclosed |
| EP-1987042-B1 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI SA (FR) | 2015-01-21 | — | — | EP | disclosed |
| US-8853208-B2 | Amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments | SANOFI (FR) | 2014-10-07 | — | — | US | disclosed |
| US-20090076002-A1 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (FR) | 2009-03-19 | — | — | US | disclosed |
| CN-101384605-A | Novel aminoalcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments | SANOFI AVENTIS (FR) | 2009-03-11 | — | — | CN | disclosed |
| EP-1987042-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | sanofi-aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| US-7285557-B2 | Pyrimidinones as melanin concentrating hormone receptor 1 | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-7285557-B2 | Pyrimidinones as melanin concentrating hormone receptor 1 | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-7285557-B2 | Pyrimidinones as melanin concentrating hormone receptor 1 | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-10-23 | — | — | US | disclosed |
| WO-2007093365-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |
| EP-1442025-B1 | PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR 1 | SMITHKLINE BEECHAM PLC (GB) | 2007-03-07 | — | — | EP | disclosed |
| CN-1571774-A | Pyrimidinones as melanin concentrating hormone receptor 1 | SMITHKLINE BEECHAM PLC (GB) | 2005-01-26 | — | — | CN | disclosed |
| US-20040220404-A1 | Pyrimidinones as melanin concentrating hormone receptor 1 | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-11-04 | — | — | US | disclosed |
| EP-1442025-A1 | PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR 1 | SMITHKLINE BEECHAM PLC (GB) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003033476-A1 | PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR 1 | SMITHKLINE BEECHAM PLC (GB) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442796-B2 | 2,3,5-substituted thiophene compound as protein kinase inhibitor | CDK2, CDK2AP2, MAP3K5 | CASP6 1682/4885TSHR 3570/4885LMNA 4101/4885 |
| US-20040220404-A1 | Pyrimidinones as melanin concentrating hormone receptor 1 | MC1R, MCHR1, MCHR2 | CASP6 4855/4885TSHR 33/4885LMNA 4420/4885 |
| US-20090076002-A1 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | AADAT, PNMT, MCHR1 | CASP6 4705/4885TSHR 783/4885LMNA 3722/4885 |
| US-20190047993-A1 | Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor | MAP3K5, MAP3K6, MAP3K9 | CASP6 1485/4885TSHR 3501/4885LMNA 4245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.