SCHEMBL4160602

SCHEMBL4160602

Cc1cc(C#N)cc(C(=O)NC2(C)CC2)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.40
EGLN1 Q9GZT9 2/20 0.37
KMT2A Q03164 1/20 0.35
ANO1 Q5XXA6 1/20 0.33
RET P07949 5/20 0.33
MALT1 Q9UDY8 1/20 0.33
PKM P14618 1/20 0.33
GCK P35557 2/20 0.32
KCNH2 Q12809 2/20 0.32
TNF P01375 1/20 0.32
IRAK4 Q9NWZ3 1/20 0.32
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10279943 0.93 DHODH (0.38) DHODHKMT2AMALT1
SCHEMBL10279971 0.92 DHODH (0.38) DHODHEGLN1KMT2AMALT1PKM
SCHEMBL4168969 0.90 DHODH (0.41) DHODHANO1MALT1PDE4APDE4B
Cyantraniliprole SCHEMBL166640 0.89 DHODH (0.42) DHODHEGLN1KMT2AMALT1PKM
Cyantraniliprole SCHEMBL29354965 0.89 DHODH (0.42) DHODHEGLN1KMT2AMALT1PKM
SCHEMBL950199 0.88 DHODH (0.42) DHODHKMT2AMALT1PKMGCK
SCHEMBL24101462 0.88 DHODH (0.43) DHODHKMT2AMALT1PKMGCK
SCHEMBL15271704 0.88 DHODH (0.43) DHODHKMT2AMALT1PKMGCK
SCHEMBL28867332 0.88 DHODH (0.43) DHODHKMT2AMALT1PKMGCK
SCHEMBL31059983 0.87 DHODH (0.42) DHODHKMT2AMALT1PKMGCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
EP-1812421-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-08-01 EP claimed
WO-2006055922-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-05-26 WO claimed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed
EP-1812421-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-08-01 EP disclosed
WO-2006055922-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S DHODH 1809/4885EGLN1 1750/4885KMT2A 478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.