SCHEMBL4168969

SCHEMBL4168969

Cc1cc(Cl)cc(C(=O)NC2(C)CC2)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.78

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.41
ANO1 Q5XXA6 2/20 0.37
MALT1 Q9UDY8 3/20 0.36
DGAT2 Q96PD7 2/20 0.34
KIF18A Q8NI77 2/20 0.33
NTRK1 P04629 3/20 0.33
GRM1 Q13255 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
TRPV1 Q8NER1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4162046 0.93 DHODH (0.39) DHODHANO1MALT1DGAT2NTRK1
SCHEMBL10280352 0.92 DHODH (0.40) DHODHMALT1DGAT2
SCHEMBL10280397 0.91 DHODH (0.39) DHODHMALT1DGAT2NTRK1TRPV1
SCHEMBL4160602 0.90 DHODH (0.40) DHODHANO1MALT1PDE4APDE4B
SCHEMBL12912066 0.89 DHODH (0.44) DHODHMALT1TRPV1
Chlorantraniliprole SCHEMBL29363261 0.88 DHODH (0.44) DHODHMALT1NTRK1TRPV1
Chlorantraniliprole SCHEMBL29551 0.88 DHODH (0.44) DHODHMALT1NTRK1TRPV1
SCHEMBL3204989 0.88 DHODH (0.40) DHODHMALT1KIF18ANTRK1
SCHEMBL902720 0.88 DHODH (0.46) DHODHMALT1TRPV1
SCHEMBL950846 0.87 DHODH (0.44) DHODHMALT1NTRK1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
EP-1812421-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-08-01 EP claimed
WO-2006055922-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-05-26 WO claimed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S DHODH 1809/4885ANO1 1229/4885MALT1 1842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.