SCHEMBL4162237

SCHEMBL4162237

Cc1cc(C#N)cc(C(=O)NCC2CCO2)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ccccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
KLKB1 P03952 13/20 0.39
FASN P49327 1/20 0.36
RORC P51449 1/20 0.36
PLG P00747 1/20 0.36
PRSS1 P07477 1/20 0.36
PRSS2 P07478 1/20 0.36
PRSS3 P35030 1/20 0.36
USP2 O75604 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4154454 0.82 KLKB1 (0.41) KLKB1PLGPRSS1PRSS2PRSS3
SCHEMBL499797 0.81 NTRK1 (0.40) ALDH1A1KLKB1RORCTSHR
SCHEMBL4165682 0.81 CNR1 (0.38)
SCHEMBL16564395 0.80 KLKB1 (0.39) KLKB1
SCHEMBL4159757 0.79 NTRK1 (0.38) ALDH1A1FASNHPGDTSHRSMN1; SMN2
SCHEMBL18060403 0.79 F10 (0.39) KLKB1
SCHEMBL13085496 0.79 CETP (0.35) KLKB1
SCHEMBL13085539 0.78 SLC2A1 (0.34) KLKB1
SCHEMBL12113655 0.77 CACNA1H (0.36) ALDH1A1
SCHEMBL12113649 0.77 CNR1 (0.37) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1812421-B9 ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-09-25 EP claimed
EP-1812421-B1 ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-04-24 EP claimed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
EP-1812421-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-08-01 EP claimed
WO-2006055922-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-05-26 WO claimed
EP-1812421-B9 ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-09-25 EP disclosed
EP-1812421-B1 ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-04-24 EP disclosed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S ALDH1A1 937/4885KLKB1 2498/4885FASN 332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.