SCHEMBL4165682

SCHEMBL4165682

Cc1cc(C#N)cc(C(=O)NCC2CC2)c1NC(=O)c1cc(Br)nn1-c1ccccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 3/20 0.38
CHRM1 P11229 5/20 0.37
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM5 P08912 1/20 0.37
CHRM3 P20309 1/20 0.37
CETP P11597 1/20 0.36
TP53 P04637 2/20 0.36
LMNA P02545 1/20 0.36
CNR2 P34972 3/20 0.36
NPC1 O15118 2/20 0.34
USP30 Q70CQ3 1/20 0.34
EGLN1 Q9GZT9 1/20 0.34
MAPT P10636 2/20 0.34
KDM4E B2RXH2 1/20 0.34
PKM P14618 1/20 0.34
RAB9A P51151 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4149532 0.90 CHRM1 (0.40) CNR1CHRM1CHRM2CHRM4CHRM5
SCHEMBL2138881 0.89 P2RX7 (0.39) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL2138320 0.87 MEN1 (0.35) CNR1CETPTP53MEN1KMT2A
SCHEMBL2137605 0.85 TP53 (0.35) CNR1CETPTP53LMNACNR2
SCHEMBL13085496 0.82 CETP (0.35) CNR1CHRM1CHRM2CHRM4CHRM5
SCHEMBL1533505 0.82 CHRM4 (0.38) CHRM4EGLN1
SCHEMBL13085539 0.82 SLC2A1 (0.34) CNR1CHRM1CHRM2CHRM4CHRM5
SCHEMBL4159757 0.81 NTRK1 (0.38) EGLN1MAPTRAB9A
SCHEMBL4162237 0.81 ALDH1A1 (0.39)
SCHEMBL2138302 0.79 P2RX7 (0.41) CHRM1CHRM2CHRM4CHRM5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S CNR1 31/4885CHRM1 40/4885CHRM2 67/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.