Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 3/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.57 |
| ▸ | BCHE | P06276 | 4/20 | 0.57 |
| ▸ | ACHE | P22303 | 4/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965743 | 0.84 | MPO (0.60) | CXCR4HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL5695121 | 0.82 | ALDH1A1 (0.79) | TP53CYP3A4CYP2D6RECQLMEN1 | |
| SCHEMBL23576309 | 0.80 | APLNR (0.71) | HTR2AHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL29816711 | 0.80 | APLNR (0.71) | HTR2AHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL4918396 | 0.78 | CHRM2 (0.79) | TP53CYP3A4CYP2D6RECQLMEN1 | |
| SCHEMBL27612104 | 0.78 | KDM4E (0.69) | TP53MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL25378299 | 0.77 | MEN1 (0.64) | CXCR4TP53CYP3A4CYP2D6RECQL | |
| SCHEMBL23023124 | 0.77 | CHRM2 (0.59) | TP53CYP3A4CYP2D6RECQLMEN1 | |
| SCHEMBL1566484 | 0.77 | ALDH1A1 (0.57) | CXCR4TP53CYP3A4CYP2D6RECQL | |
| SCHEMBL20344007 | 0.77 | CHRNB4 (0.52) | HTR2AHTR2CHTR2BTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022054-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2012-01-26 | — | — | US | disclosed |
| EP-2376431-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010066847-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | CELLVIR (FR) | 2010-06-17 | — | — | WO | disclosed |
| EP-2196453-A1 | Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents | Cellvir (FR) | 2010-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022054-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | HAVCR2, MAVS, EIF2AK2 | CXCR4 126/4885HTR2A 3460/4885HTR2C 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.