Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174099 | 0.87 | PTGS2 (0.41) | NR1H2NR1H3ESR1KMOPTGS2 | |
| SCHEMBL27765248 | 0.85 | NR1H2 (0.40) | NR1H2NR1H3ESR1KMOPTGS2 | |
| SCHEMBL4164434 | 0.80 | ALOX5AP (0.43) | NR1H2NR1H3SLC40A1SCN9A | |
| SCHEMBL4167820 | 0.78 | AR (0.38) | NR1H2NR1H3MAPK14SCN9A | |
| SCHEMBL27786915 | 0.78 | ESR1 (0.40) | NR1H2NR1H3ESR1KMOHSD11B1 | |
| SCHEMBL27786914 | 0.71 | SCN9A (0.57) | ESR1HSD11B1SCN9A | |
| SCHEMBL4174108 | 0.71 | NR1H3 (0.46) | NR1H2NR1H3SLC40A1SCN9A | |
| SCHEMBL27765478 | 0.71 | NR1H2 (0.37) | NR1H2NR1H3ESR1SLC40A1 | |
| SCHEMBL28780680 | 0.70 | P2RX7 (0.37) | NR1H2NR1H3ESR1SLC40A1ENPP1 | |
| SCHEMBL4167348 | 0.70 | NR1H2 (0.41) | NR1H2NR1H3ESR1PTGS2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |