Sugi Predict

Sugi Predict / Compounds / SCHEMBL4165192

SCHEMBL4165192

SCHEMBL4165192

CC(=O)Nc1c(N(C)C)cnn(C)c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BPTF Q12830 3/20 0.40
▸ MAPT P10636 1/20 0.36
▸ COPS5 Q92905 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ KAT2B Q92831 2/20 0.35
▸ BRD9 Q9H8M2 1/20 0.35
▸ POLB P06746 1/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ CNR1 P21554 2/20 0.33
▸ CNR2 P34972 2/20 0.33
▸ NPC1 O15118 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ CYP1A2 P05177 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ MEN1 O00255 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ PTK2 Q05397 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4170118 0.78 BPTF (0.52) BPTFMAPTCOPS5ALDH1A1KAT2B
SCHEMBL4158950 0.70 ROCK2 (0.38) MAPTALDH1A1POLBKMT2APTK2
SCHEMBL2544338 0.69 RAB9A (0.55) BPTFMAPTALDH1A1KAT2BBRD9
SCHEMBL7011309 0.68 KAT2B (0.37) BPTFALDH1A1KAT2BBRD9CNR1
SCHEMBL7017552 0.67 ALDH1A1 (0.39) BPTFMAPTALDH1A1KAT2BBRD9
SCHEMBL13942551 0.64 RAB9A (0.42) MAPTALDH1A1POLBRXFP1NPC1
SCHEMBL9207223 0.64 CYP1A2 (0.40) BPTFALDH1A1NPC1RAB9ACYP1A2
SCHEMBL21232988 0.62 MAPK1 (0.47) BPTFMAPTALDH1A1KAT2BBRD9
SCHEMBL21232989 0.62 SMPD3 (0.40) MAPTALDH1A1POLBNPC1RAB9A
SCHEMBL7300318 0.61 MEN1 (0.59) POLBRXFP1NPC1RAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090012088-A1 Compounds for the Treatment of Neurodegeneration and Stroke THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2009-01-08 — — US disclosed
US-20090012088-A1 Compounds for the Treatment of Neurodegeneration and Stroke THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2009-01-08 — — US disclosed
US-20090012088-A1 Compounds for the Treatment of Neurodegeneration and Stroke THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2009-01-08 — — US disclosed
US-20070032496-A1 Compounds for the Treatment of Neurodegeneration and Stroke THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2007-02-08 — — US disclosed
US-20070032496-A1 Compounds for the Treatment of Neurodegeneration and Stroke THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2007-02-08 — — US disclosed
US-20070032496-A1 Compounds for the Treatment of Neurodegeneration and Stroke THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2007-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032496-A1 Compounds for the Treatment of Neurodegeneration and Stroke PARP1, PARP12, PARP11 BPTF 3277/4885MAPT 239/4885COPS5 2755/4885
US-20090012088-A1 Compounds for the Treatment of Neurodegeneration and Stroke PARP1, PARP12, PARP11 BPTF 3277/4885MAPT 239/4885COPS5 2755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.