SCHEMBL4165238

SCHEMBL4165238

CC(=O)Oc1c(C(C)=O)c(OC(C)=O)c2c(=O)c(OC(C)=O)c(-c3ccc(O)c(O)c3)oc2c1C(C)=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 1/20 0.46
▸ POLH Q9Y253 2/20 0.46
▸ KDM4E B2RXH2 2/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ MAPT P10636 2/20 0.46
▸ APEX1 P27695 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ MMP1 P03956 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ HTT P42858 1/20 0.46
▸ RECQL P46063 1/20 0.46
▸ BLM P54132 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ XDH P47989 1/20 0.46
▸ EPHX2 P34913 1/20 0.45
▸ KDR P35968 1/20 0.45
▸ PLG P00747 1/20 0.45
▸ NOX4 Q9NPH5 1/20 0.45
▸ TUBB4A P04350 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11411328 0.81 EPHX2 (0.46) APPPOLHKDM4EMEN1MAPT
SCHEMBL4175201 0.77 POLH (0.76) APPPOLHKDM4EMEN1MAPT
SCHEMBL31236662 0.77 POLH (0.76) APPPOLHKDM4EMEN1MAPT
SCHEMBL4157261 0.77 SRC (0.44) APPPOLHKDM4EMEN1MAPT
SCHEMBL4169452 0.74 ALOX5 (0.49) POLHALOX5
SCHEMBL31250385 0.74 KDM4E (0.56) APPPOLHKDM4EMEN1MAPT
SCHEMBL16882942 0.74 KDM4E (0.68) APPPOLHKDM4EMEN1MAPT
SCHEMBL4165925 0.74 ALOX5 (0.50) POLHALOX5
SCHEMBL4155997 0.74 ALOX5 (0.50) POLHALOX5
SCHEMBL4164333 0.74 ALOX5 (0.50) POLHALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090130051-A1 Flavonoid Compounds and Uses Thereof HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) 2009-05-21 — — US claimed
EP-0570475-A1 PHARMACEUTICAL PREPARATION FOR THE THERAPY OF TUMORS, PARTICULARLY OVARIAN AND HAEMOPOIETIC SYSTEM TUMORS, CONTAINING QUERCETIN COMPOUNDS AS ACTIVE SUBSTANCES ROMEO, Francesco (IT) 1993-11-24 — — EP claimed
WO-1992013851-A1 PHARMACEUTICAL PRODUCT FOR THE THERAPY OF TUMORS, PARTICULARLY OVARIAN AND HAEMOPOIETIC SYSTEM TUMORS, CONTAINING QUERCETIN COMPOUNDS AS ACTIVE SUBSTANCES ROMEO, FRANCESCO (IT) 1992-08-20 — — WO claimed
US-11458200-B2 Constructs, agents, and methods for facilitated ablation of cardiac tissue Sauer, William (US) 2022-10-04 — — US disclosed
US-11229622-B2 Cosmetological and pharmaceutical composition based on combinatorial quercetin derivative FARBER BORIS (US) 2022-01-25 — — US disclosed
US-20210205263-A1 COSMETOLOGICAL AND PHARMACEUTICAL COMPOSITION BASED ON COMBINATORIAL QUERCETIN DERIVATIVE FARBER BORIS SLAVINOVICH (RU) 2021-07-08 — — US disclosed
US-20190328877-A1 Constructs, Agents, and Methods for Facilitated Ablation of Cardiac Tissue NGUYEN, DUY 2019-10-31 — — US disclosed
EP-3451959-A1 CONSTRUCTS, AGENTS, AND METHODS FOR FACILITATED ABLATION OF CARDIAC TISSUE The Regents of The University of Colorado, A Body Corporate (US) 2019-03-13 — — EP disclosed
WO-2017192804-A1 CONSTRUCTS, AGENTS, AND METHODS FOR FACILITATED ABLATION OF CARDIAC TISSUE THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2017-11-09 — — WO disclosed
EP-0524744-B1 Base board for printed circuit board MITSUBISHI GAS CHEMICAL CO (JP) 1995-06-21 — — EP disclosed
US-5266385-A For inspection of printed circuit patterns MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1993-11-30 — — US disclosed
EP-0570475-A1 PHARMACEUTICAL PREPARATION FOR THE THERAPY OF TUMORS, PARTICULARLY OVARIAN AND HAEMOPOIETIC SYSTEM TUMORS, CONTAINING QUERCETIN COMPOUNDS AS ACTIVE SUBSTANCES ROMEO, Francesco (IT) 1993-11-24 — — EP disclosed
EP-0570475-A1 PHARMACEUTICAL PREPARATION FOR THE THERAPY OF TUMORS, PARTICULARLY OVARIAN AND HAEMOPOIETIC SYSTEM TUMORS, CONTAINING QUERCETIN COMPOUNDS AS ACTIVE SUBSTANCES ROMEO, Francesco (IT) 1993-11-24 — — EP disclosed
EP-0524744-A1 Base board for printed circuit board MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1993-01-27 — — EP disclosed
WO-1992013851-A1 PHARMACEUTICAL PRODUCT FOR THE THERAPY OF TUMORS, PARTICULARLY OVARIAN AND HAEMOPOIETIC SYSTEM TUMORS, CONTAINING QUERCETIN COMPOUNDS AS ACTIVE SUBSTANCES ROMEO, FRANCESCO (IT) 1992-08-20 — — WO disclosed
WO-1992013851-A1 PHARMACEUTICAL PRODUCT FOR THE THERAPY OF TUMORS, PARTICULARLY OVARIAN AND HAEMOPOIETIC SYSTEM TUMORS, CONTAINING QUERCETIN COMPOUNDS AS ACTIVE SUBSTANCES ROMEO, FRANCESCO (IT) 1992-08-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090130051-A1 Flavonoid Compounds and Uses Thereof CAT, NQO1, GPX4 APP 4633/4885POLH 3392/4885KDM4E 4144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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