Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Detrothyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 13/20 | 0.98 |
| ▸ | THRA known ✓ | P10827 | 9/20 | 0.76 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.98 |
| ▸ | LMNA | P02545 | 6/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.98 |
| ▸ | POLB | P06746 | 3/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | HPGD | P15428 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | MAPT | P10636 | 2/20 | 0.98 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.98 |
| ▸ | PCNA | P12004 | 5/20 | 0.76 |
| ▸ | PPARG | P37231 | 3/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL29684887 | 0.99 | THRB (1.00) | USP2L3MBTL1THRBMEN1KMT2A | |
| Detrothyronine SCHEMBL29378991 | 0.99 | THRB (1.00) | USP2L3MBTL1THRBMEN1KMT2A | |
| Detrothyronine SCHEMBL41654 | 0.99 | THRB (1.00) | USP2L3MBTL1THRBMEN1KMT2A | |
| Dextrothyroxine SCHEMBL15569465 | 0.94 | THRB (0.91) | USP2L3MBTL1THRBMEN1KMT2A | |
| Detrothyronine SCHEMBL1461521 | 0.90 | THRB (0.84) | USP2L3MBTL1THRBMEN1KMT2A | |
| Liothyronine SCHEMBL8300 | 0.86 | THRB (1.00) | USP2L3MBTL1THRBMEN1KMT2A | |
| Dextrothyroxine SCHEMBL838270 | 0.86 | USP2 (0.76) | USP2L3MBTL1THRBMEN1KMT2A | |
| Dextrothyroxine SCHEMBL2327406 | 0.86 | USP2 (0.76) | USP2L3MBTL1THRBMEN1KMT2A | |
| SCHEMBL4439596 | 0.86 | THRB (0.78) | USP2L3MBTL1THRBMEN1KMT2A | |
| Detrothyronine SCHEMBL8301 | 0.86 | THRB (1.00) | USP2L3MBTL1THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1773 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704805-A2 | ORAL SOLUTION COMPRISING LIOTHYRONINE SODIUM | LABOMED PHARMACEUTICAL COMPANY S.A. (GR) | 2026-03-11 | — | — | EP | claimed |
| WO-2024227895-A2 | ORAL SOLUTION COMPRISING LIOTHYRONINE SODIUM | LABOMED PHARMACEUTICAL COMPANY S.A. (GR) | 2024-11-07 | — | — | WO | claimed |
| CN-118755662-A | Islet organoid culture reagent and culture method | 博奥生物集团有限公司 | 2024-10-11 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-20240041773-A1 | POWDER MIXING DEVICE, AND USES THEREOF | UNIV CONNECTICUT (US) | 2024-02-08 | — | — | US | claimed |
| US-20230201204-A1 | Methods and Compositions for Treating Thyroid-Related Medical Conditions with Reduced Folates | SCOTT III LINZY O (US) | 2023-06-29 | — | — | US | claimed |
| CN-115884959-A | Biologically active phenolate ion complexes | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 2023-03-31 | — | — | CN | claimed |
| EP-4139269-A1 | BIOACTIVE PHENOLATE IONIC COMPLEXES | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2023-03-01 | — | — | EP | claimed |
| US-20220354853-A1 | Methods and Compositions for Treating Thyroid-Related Medical Conditions with Reduced Folates | SCOTT III LINZY O (US) | 2022-11-10 | — | — | US | claimed |
| WO-2022221480-A1 | STABLE LIQUID ORAL DOSAGE FORMS OF LIOTHYRONINE | VERTICE PHARMA LLC (US) | 2022-10-20 | — | — | WO | claimed |
| US-6190696-B1 | MIXING LIOTHYRONINE SODIUM, IODINE SALT MIXED WITH CARRIER, DISINTEGRANT, LUBRICANT, BINDER AND FILLER | GROENEWOUD PIETER J (US) | 2001-02-20 | — | — | US | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| WO-1999063969-A1 | STABILIZED THYROXINE MEDICATIONS | GROENEWOUD PIETER J (US) | 1999-12-16 | — | — | WO | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0751769-A4 | MEDICAL TREATMENT USING THYROID HORMONES | UNIV MICHIGAN (US) | 1998-05-27 | — | — | EP | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0751769-A1 | MEDICAL TREATMENT USING THYROID HORMONES | The Regents of The University of Michigan (US) | 1997-01-08 | — | — | EP | claimed |
| WO-1995000135-A1 | MEDICAL TREATMENT USING THYROID HORMONES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1995-01-05 | — | — | WO | claimed |