Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Detrothyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 13/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 9/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.98 |
| ▸ | PCNA | P12004 | 5/20 | 0.78 |
| ▸ | PPARG | P37231 | 3/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL29684887 | 1.00 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL41654 | 1.00 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL41655 | 0.99 | USP2 (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Dextrothyroxine SCHEMBL15569465 | 0.95 | THRB (0.91) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL1461521 | 0.92 | THRB (0.84) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL16124483 | 0.88 | THRB (0.81) | THRBMEN1KMT2ALMNAUSP2 | |
| Rathyronine SCHEMBL123365 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Liothyronine SCHEMBL3287278 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL8301 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Liothyronine SCHEMBL8300 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119391213-A | Automobile original factory exterior water-based black paint and preparation method thereof | 雅图高新材料股份有限公司 | 2025-02-07 | — | — | CN | disclosed |
| EP-3947434-A2 | ENGINEERED PLATELETS FOR TARGETED DELIVERY OF A THERAPEUTIC AGENT | JPV01 Ltd (GB) | 2022-02-09 | — | — | EP | disclosed |