Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Detrothyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 13/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 9/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.98 |
| ▸ | PCNA | P12004 | 5/20 | 0.78 |
| ▸ | PPARG | P37231 | 3/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL29684887 | 1.00 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL29378991 | 1.00 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL41655 | 0.99 | USP2 (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Dextrothyroxine SCHEMBL15569465 | 0.95 | THRB (0.91) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL1461521 | 0.92 | THRB (0.84) | THRBMEN1KMT2ALMNAUSP2 | |
| Rathyronine SCHEMBL123365 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Liothyronine SCHEMBL8300 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL8301 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL16124483 | 0.88 | THRB (0.81) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL4439596 | 0.88 | THRB (0.78) | THRBMEN1KMT2ALMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3212 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704805-A2 | ORAL SOLUTION COMPRISING LIOTHYRONINE SODIUM | LABOMED PHARMACEUTICAL COMPANY S.A. (GR) | 2026-03-11 | — | — | EP | claimed |
| EP-4630022-A1 | USE OF CONDITIONED MEDIUM OF CORD LINING MESENCHYMAL STEM CELLS FOR HEALING AND/OR PREVENTING THE FORMATION AND/OR RECURRENCE OF A WOUND OR A DAMAGED SKIN AREA | CellResearch Corporation Pte. Ltd. (SG) | 2025-10-15 | — | — | EP | claimed |
| EP-4619012-A1 | USE OF CONDITIONED MEDIUM DERIVED FROM CULTIVATION OF MESENCHYMAL STEM CELLS OF THE UMBILICAL CORD FOR INDUCING, STIMULATING AND PROMOTING HAIR GROWTH AND REGENERATION | CellResearch Corporation Pte. Ltd. (SG) | 2025-09-24 | — | — | EP | claimed |
| US-20250290043-A1 | METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD, A MESENCHYMAL STEM CELL POPULATION ISOLATED FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD AND A CELL CULTURE MEDIUM FOR ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2025-09-18 | — | — | US | claimed |
| CN-112262211-B | Method for inducing or improving wound healing property of mesenchymal stem cells | 细胞研究私人有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-109804063-B | Method for separating mesenchymal stem cells from umbilical cord amniotic membrane by adopting cell culture medium | 细胞研究私人有限公司 | 2025-02-25 | — | — | CN | claimed |
| EP-3523421-B1 | A METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM UMBILICAL CORD AMNIOTIC MEMBRANE USING A CELL CULTURE MEDIUM | CELLRESEARCH CORP PTE LTD (SG) | 2024-12-04 | — | — | EP | claimed |
| WO-2024227895-A2 | ORAL SOLUTION COMPRISING LIOTHYRONINE SODIUM | LABOMED PHARMACEUTICAL COMPANY S.A. (GR) | 2024-11-07 | — | — | WO | claimed |
| CN-118755662-A | Islet organoid culture reagent and culture method | 博奥生物集团有限公司 | 2024-10-11 | — | — | CN | claimed |
| CN-118546882-A | Primary retina cell separation and culture method and multi-mode signal detection method | 天津大学 | 2024-08-27 | — | — | CN | claimed |
| US-6190696-B1 | MIXING LIOTHYRONINE SODIUM, IODINE SALT MIXED WITH CARRIER, DISINTEGRANT, LUBRICANT, BINDER AND FILLER | GROENEWOUD PIETER J (US) | 2001-02-20 | — | — | US | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| WO-1999063969-A1 | STABILIZED THYROXINE MEDICATIONS | GROENEWOUD PIETER J (US) | 1999-12-16 | — | — | WO | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0751769-A4 | MEDICAL TREATMENT USING THYROID HORMONES | UNIV MICHIGAN (US) | 1998-05-27 | — | — | EP | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0751769-A1 | MEDICAL TREATMENT USING THYROID HORMONES | The Regents of The University of Michigan (US) | 1997-01-08 | — | — | EP | claimed |
| WO-1995000135-A1 | MEDICAL TREATMENT USING THYROID HORMONES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1995-01-05 | — | — | WO | claimed |