SCHEMBL4167964

SCHEMBL4167964

CC(C)(C)OC(=O)N(C(=N)NCCOc1ccc(CCCCNC(=N)NC(=O)c2nc(Cl)c(N)nc2N)cc1)C(=O)OC(C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCNN1A P37088 19/20 0.50
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2329793 0.90 SCNN1A (0.53) SCNN1A
SCHEMBL938310 0.89 SCNN1A (0.43) SCNN1A
SCHEMBL2329956 0.88 SCNN1A (0.47) SCNN1AKCNH2
SCHEMBL2286255 0.87 SCNN1A (0.51) SCNN1A
SCHEMBL10028721 0.85 SCNN1A (0.57) SCNN1AKCNH2
SCHEMBL14268265 0.85 SCNN1A (0.59) SCNN1AKCNH2
SCHEMBL17809354 0.85 SCNN1A (0.59) SCNN1A
SCHEMBL16572343 0.85 SCNN1A (0.51) SCNN1AKCNH2
SCHEMBL12908911 0.85 SCNN1A (0.48) SCNN1A
SCHEMBL9913778 0.85 SCNN1A (0.60) SCNN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090062308-A1 METHODS OF USING SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2009-03-05 US disclosed
US-20060142306-A1 Bronchodilator agents; respiratory system disorders; skin disorders ; asthma; hypotensive agents CYFI, INC. (US) 2006-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060142306-A1 Bronchodilator agents; respiratory system disorders; skin disorders ; asthma; hypotensive agents ADRB2, ADRB3, ADRA1D SCNN1A 92/4885KCNH2 63/4885
US-20090062308-A1 METHODS OF USING SODIUM CHANNEL BLOCKERS SCN1B, KCNN3, SCN2B SCNN1A 30/4885KCNH2 14/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.