SCHEMBL9913778

SCHEMBL9913778

N=C(N)NCCOc1ccc(CCCCNC(=N)NC(=O)c2nc(Cl)c(N)nc2N)cc1

nearest known ligand 0.60

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SCNN1A P37088 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1961462 0.99 SCNN1A (0.59) SCNN1A
SCHEMBL17809354 0.94 SCNN1A (0.59) SCNN1A
SCHEMBL10115655 0.92 SCNN1A (0.53) SCNN1A
SCHEMBL12120548 0.92 SCNN1A (0.51) SCNN1A
SCHEMBL18626304 0.92 SCNN1A (0.62) SCNN1A
SCHEMBL10028721 0.92 SCNN1A (0.57) SCNN1A
SCHEMBL9913769 0.92 SCNN1A (0.69) SCNN1A
SCHEMBL14268265 0.92 SCNN1A (0.59) SCNN1A
SCHEMBL2328611 0.92 SCNN1A (0.59) SCNN1A
SCHEMBL9913762 0.92 SCNN1A (0.69) SCNN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190241528-A1 SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2019-08-08 US disclosed
US-10167266-B2 Sodium channel blockers PARION SCIENCES, INC. (US) 2019-01-01 US disclosed
US-20180092915-A1 SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS PARION SCIENCES, INC. (US) 2018-04-05 US disclosed
US-20180092915-A1 SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS PARION SCIENCES, INC. (US) 2018-04-05 US disclosed
US-9849129-B2 Sodium channel blockers for skin disorders PARION SCIENCES, INC. (US) 2017-12-26 US disclosed
US-9849129-B2 Sodium channel blockers for skin disorders PARION SCIENCES, INC. (US) 2017-12-26 US disclosed
US-20170267650-A1 SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2017-09-21 US disclosed
US-20170267650-A1 SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2017-09-21 US disclosed
US-20170020870-A1 SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS PARION SCIENCES, INC. 2017-01-26 US disclosed
US-20150376146-A1 SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2015-12-31 US disclosed
US-20080293740-A1 METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS PARION SCIENCES, INC. (US) 2008-11-27 US disclosed
WO-2008124496-A1 METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH, AND CENTRAL NERVOUS SYSTEM DISORDERS PARION SCIENCES, INC. (US) 2008-10-16 WO disclosed
WO-2008124491-A1 PYRAZINOYLGUANIDINE COMPOUNDS FOR USE TASTE MODULATORS PARION SCIENCES, INC. (US) 2008-10-16 WO disclosed
US-20080249109-A1 PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS PARION SCIENCES, INC. (US) 2008-10-09 US disclosed
US-20080249109-A1 PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS PARION SCIENCES, INC. (US) 2008-10-09 US disclosed
US-20080090841-A1 METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES PARION SCIENCES, INC. (US) 2008-04-17 US disclosed
US-20080090841-A1 METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES PARION SCIENCES, INC. (US) 2008-04-17 US disclosed
WO-2008031028-A2 METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES PARION SCIENCES, INC. (US) 2008-03-13 WO disclosed
US-20070265280-A1 METHODS OF USING SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2007-11-15 US disclosed
US-20070265280-A1 METHODS OF USING SODIUM CHANNEL BLOCKERS PARION SCIENCES, INC. (US) 2007-11-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170267650-A1 SODIUM CHANNEL BLOCKERS HCN4, SCN2B, SCN5A SCNN1A 12/4885
US-20180092915-A1 SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS SCNN1B, SCNN1A, SCNN1G SCNN1A 2/4885
US-10167266-B2 Sodium channel blockers SCNN1B, SCNN1A, SCNN1G SCNN1A 2/4885
US-20080249109-A1 PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS TAS2R5, TAS2R9, TAS2R19 SCNN1A 65/4885
US-20080293740-A1 METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS ASIC1, ASIC3, TRPV1 SCNN1A 75/4885
US-20150376146-A1 SODIUM CHANNEL BLOCKERS HCN4, SCN2B, SCN5A SCNN1A 12/4885
US-20080090841-A1 METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES SCNN1B, SLC10A2, SCNN1A SCNN1A 3/4885
US-20070265280-A1 METHODS OF USING SODIUM CHANNEL BLOCKERS SCN1B, KCNN3, SCN2B SCNN1A 30/4885
US-20170020870-A1 SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS SCNN1B, SCNN1A, SCNN1G SCNN1A 2/4885
US-20190241528-A1 SODIUM CHANNEL BLOCKERS HCN4, SCN2B, SCN5A SCNN1A 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.