Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F known ✓ | P30939 | 1/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 5/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13997973 | 0.98 | BAZ2A (0.52) | BAZ2AGSK3BDYRK1AAOC3HPGDS | |
| SCHEMBL13754523 | 0.87 | KDM1A (0.41) | BAZ2AGSK3BDYRK1ANPC1RAB9A | |
| Tert-Butyl Formate SCHEMBL27828647 | 0.85 | BAZ2A (0.45) | BAZ2AGSK3BDYRK1AAOC3HPGDS | |
| SCHEMBL491211 | 0.84 | HPGDS (0.46) | BAZ2AGSK3BDYRK1AAOC3HPGDS | |
| Hydrochloric Acid SCHEMBL27895594 | 0.84 | BAZ2A (0.48) | BAZ2AGSK3BDYRK1AAOC3HPGDS | |
| SCHEMBL27100100 | 0.84 | PIM1 (0.40) | BAZ2AGSK3BDYRK1ANPC1RAB9A | |
| SCHEMBL417132 | 0.83 | AOC3 (0.47) | BAZ2AGSK3BDYRK1AAOC3HPGDS | |
| SCHEMBL11912169 | 0.83 | PIM1 (0.44) | BAZ2AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL31705780 | 0.82 | PLAT (0.45) | BAZ2AGSK3BDYRK1AAOC3HPGDS | |
| SCHEMBL14379269 | 0.82 | PLAT (0.45) | BAZ2AGSK3BDYRK1AAOC3HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563786-B1 | Ketoheteroarylpiperidine and piperazine derivatives as fungicides | BAYER IP GMBH (DE) | 2016-11-02 | — | — | EP | disclosed |
| US-9357779-B2 | Ketoheteroarylpiperdine and -piperazine derivatives as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-06-07 | — | — | US | disclosed |
| EP-2376487-B1 | THIAZOLYL OXIME ETHER AND HYDRAZONES AS PLANT PROTECTION AGENT | BAYER IP GMBH (DE) | 2016-01-06 | — | — | EP | disclosed |
| US-9220266-B2 | Ketoheteroarylpiperidine and -piperazine derivatives as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-29 | — | — | US | disclosed |
| US-9215875-B2 | Thiazolyl oxime ethers and hydrazones as crop protection agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-22 | — | — | US | disclosed |
| US-20140296289-A1 | Thiazolyl Oxime Ethers and Hydrazones as Crop Protection Agents | BAYER CROPSCIENCE AG (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8697878-B2 | Thiazolyl oxime ethers and hydrazones as crop protection agents | BAYER CROPSCIENCE AG (DE) | 2014-04-15 | — | — | US | disclosed |
| US-20130274292-A1 | Ketoheteroarylpiperdine and -Piperazine Derivatives as Fungicides | BAYER CROPSCIENCE AG (DE) | 2013-10-17 | — | — | US | disclosed |
| US-20110312999-A1 | Ketoheteroarylpiperidine and -Piperazine Derivatives as Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-12-22 | — | — | US | disclosed |
| EP-2376487-A1 | THIAZOLYL OXIME ETHER AND HYDRAZONES ASL PLANT PROTECTION AGENT | Bayer CropScience AG (DE) | 2011-10-19 | — | — | EP | disclosed |
| US-20100190828-A1 | Thiazolyl oxime ethers and hydrazones as crop protection agents | BAYER CROPSCIENCE AG (DE) | 2010-07-29 | — | — | US | disclosed |
| WO-2010066353-A1 | THIAZOLYL OXIME ETHER AND HYDRAZONES ASL PLANT PROTECTION AGENT | BAYER CROPSCIENCE AG (DE) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296289-A1 | Thiazolyl Oxime Ethers and Hydrazones as Crop Protection Agents | OXSR1, FOXO1, HAX1 | HTR1F 3097/4885BAZ2A 792/4885GSK3B 1587/4885 |
| US-20100190828-A1 | Thiazolyl oxime ethers and hydrazones as crop protection agents | OXSR1, FOXO1, HAX1 | HTR1F 3097/4885BAZ2A 792/4885GSK3B 1587/4885 |
| US-20130274292-A1 | Ketoheteroarylpiperdine and -Piperazine Derivatives as Fungicides | CYP4Z1, CYP51A1, CYP1A1 | HTR1F 2541/4885BAZ2A 140/4885GSK3B 3336/4885 |
| US-20110312999-A1 | Ketoheteroarylpiperidine and -Piperazine Derivatives as Fungicides | CYP4Z1, CYP51A1, KCNH1 | HTR1F 3482/4885BAZ2A 155/4885GSK3B 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.