Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.81 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923199 | 1.00 | CES2 (0.81) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL3176325 | 0.90 | CES2 (1.00) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL4848676 | 0.89 | CES2 (0.89) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL8188025 | 0.85 | CES2 (0.59) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL40186 | 0.84 | SRD5A2 (0.77) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL29433907 | 0.84 | SRD5A2 (0.77) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL935957 | 0.83 | CES2 (0.79) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL11725067 | 0.83 | CES2 (0.79) | CES2SRD5A2LMNAMAOBKCNK3 | |
| Hydrochloric Acid SCHEMBL10387616 | 0.82 | SRD5A2 (0.74) | CES2SRD5A2LMNAMAOBKCNK3 | |
| SCHEMBL29208534 | 0.82 | SRD5A2 (0.74) | CES2SRD5A2LMNAMAOBKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111056890-B | Method for preparing aryl ketone by free radical-free radical coupling reaction of ketoacid decarboxylation and fatty aldehyde decarbonylation based on iron catalysis | 湘潭大学 | 2022-10-14 | — | — | CN | claimed |
| CN-111056890-A | Method for preparing aryl ketone by free radical-free radical coupling reaction of ketoacid decarboxylation and fatty aldehyde decarbonylation based on iron catalysis | 湘潭大学 | 2020-04-24 | — | — | CN | claimed |
| CN-108101856-A | Acyl group substitutes the preparation method of pyrazine compounds | 河南农业大学 | 2018-06-01 | — | — | CN | claimed |
| EP-0975584-B1 | SYNTHESIS AND USE OF ALPHA-KETOAMIDE DERIVATIVES AND ARRAYS | ARQULE INC (US) | 2002-09-25 | — | — | EP | claimed |
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| CN-111056890-B | Method for preparing aryl ketone by free radical-free radical coupling reaction of ketoacid decarboxylation and fatty aldehyde decarbonylation based on iron catalysis | 湘潭大学 | 2022-10-14 | — | — | CN | disclosed |
| CN-114956933-A | Marker containing isotope oxygen atom and preparation method and application thereof | 清华大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-114409602-A | Method for synthesizing alpha-keto acid by using oxalyl chloride and Grignard reagent as raw materials | 武汉大学 | 2022-04-29 | — | — | CN | disclosed |
| WO-2021221169-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2021-11-04 | — | — | WO | disclosed |
| CN-109232282-B | Synthetic method of 2-aminobenzophenone compound | 新乡医学院 | 2021-03-02 | — | — | CN | disclosed |
| CN-111056890-A | Method for preparing aryl ketone by free radical-free radical coupling reaction of ketoacid decarboxylation and fatty aldehyde decarbonylation based on iron catalysis | 湘潭大学 | 2020-04-24 | — | — | CN | disclosed |
| WO-2008077646-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-07-03 | — | — | WO | disclosed |
| EP-0975584-A1 | SYNTHESIS AND USE OF $g(a)-KETOAMIDE DERIVATIVES AND ARRAYS | ARQULE, INC. (US) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046559-A1 | SYNTHESIS AND USE OF α-KETOAMIDE DERIVATIVES AND ARRAYS | ARQULE, INC. (US) | 1998-10-22 | — | — | WO | disclosed |
| EP-0386940-A1 | 6-Beta-(alpha-etherified oxymino)-acyl amino penicillins | BEECHAM GROUP PLC (GB) | 1990-09-12 | — | — | EP | disclosed |
| US-4296244-A | (3-Trifluoromethylphenyl)-alpha-hydroxyacetic acid and process for preparation | HOOKER CHEMICALS & PLASTICS CORP. (US) | 1981-10-20 | — | — | US | disclosed |
| US-4268687-A | Method of making methyl and ethyl esters of (3-trifluoromethylphenyl)-acetic acid | HOOKER CHEMICALS & PLASTICS CORP. (US) | 1981-05-19 | — | — | US | disclosed |
| US-4238413-A | (3-Trifluoromethyl)-benzoyl cyanide and process for its production | HOOKER CHEMICALS & PLASTICS CORP. (US) | 1980-12-09 | — | — | US | disclosed |
| US-3969401-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | WILLIAM H. RORER, INC. (US) | 1976-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | TRPV4, TRPV1, TRPV2 | CES2 4819/4885SRD5A2 1881/4885LMNA 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.