Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162417 | 0.87 | — | — | |
| SCHEMBL4491809 | 0.81 | EGFR (0.32) | RXRA | |
| SCHEMBL4172027 | 0.74 | AAK1 (0.33) | — | |
| SCHEMBL3271973 | 0.70 | ALDH1A1 (0.34) | RXRA | |
| SCHEMBL3929768 | 0.70 | RXRA (0.30) | RXRA | |
| SCHEMBL4502806 | 0.67 | MAP2K1 (0.33) | — | |
| SCHEMBL3929762 | 0.66 | GPR119 (0.34) | RXRA | |
| SCHEMBL3930866 | 0.65 | — | — | |
| SCHEMBL57513 | 0.62 | DGAT1 (0.41) | — | |
| SCHEMBL3271971 | 0.61 | RXRA (0.33) | RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043744-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008895-A1 | GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008887-A2 | GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |