Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186321 | 0.89 | SIGMAR1 (0.36) | KDM4ESIGMAR1GAAMAPTAVPR1A | |
| SCHEMBL4186330 | 0.89 | SIGMAR1 (0.36) | KDM4ESIGMAR1GAAMAPTAVPR1A | |
| SCHEMBL4174568 | 0.84 | KDM4E (0.34) | KDM4EADRB2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL4172778 | 0.84 | ADRB2 (0.38) | KDM4EADRB2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL4183629 | 0.83 | DDB1 (0.38) | KDM4EADRB2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3981476 | 0.82 | MTNR1A (0.42) | KDM4EADRB2ALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL4186572 | 0.78 | STAT3 (0.39) | KDM4EADRB2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3289249 | 0.77 | SIGMAR1 (0.35) | KDM4EADRB2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL4172529 | 0.76 | BRD4 (0.35) | KDM4EADRB2ADORA3ADORA2AALDH1A1 | |
| SCHEMBL4136760 | 0.76 | DDB1 (0.38) | ADRB2ADORA3ADORA2AALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| EP-1824871-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006050940-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885ADRB2 3053/4885ADORA3 4738/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | KDM4E 4136/4885ADRB2 3016/4885ADORA3 4701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.