Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178090 | 0.89 | SIGMAR1 (0.37) | BRD4ALDH1A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL4178092 | 0.89 | SIGMAR1 (0.35) | BRD4ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3981476 | 0.86 | MTNR1A (0.42) | ALDH1A1KDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL4879429 | 0.86 | ALDH1A1 (0.34) | BRD4ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4180098 | 0.83 | DDB1 (0.37) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL3289249 | 0.83 | SIGMAR1 (0.35) | BRD4ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4174568 | 0.80 | KDM4E (0.34) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL4136760 | 0.78 | DDB1 (0.38) | ALDH1A1MEN1KMT2ASIGMAR1CNR2 | |
| SCHEMBL4175922 | 0.77 | KDM4E (0.42) | ALDH1A1KDM4EHPGDHSD17B10CYP1A2 | |
| SCHEMBL4887129 | 0.77 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| EP-1824871-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006050940-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | BRD4 2030/4885ALDH1A1 4011/4885KDM4E 3897/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | BRD4 3197/4885ALDH1A1 3772/4885KDM4E 4136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.