Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.43 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.43 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715497 | 0.78 | IRAK4 (0.48) | PIM1IRAK4IRAK1MAP4K3PAK1 | |
| SCHEMBL4172633 | 0.74 | IRAK1 (0.48) | PIM1IRAK4IRAK1CYP2C19FLT3 | |
| SCHEMBL30113065 | 0.73 | PIM1 (0.64) | PIM1ACVR1IRAK4IRAK1CYP1A2 | |
| SCHEMBL3723926 | 0.73 | IRAK4 (0.47) | PIM1IRAK4IRAK1CHRNB2CHRNA4 | |
| SCHEMBL3718389 | 0.73 | MAP4K3 (0.53) | PIM1IRAK4IRAK1MAP4K3ALK | |
| SCHEMBL3719529 | 0.72 | MAP4K3 (0.47) | PIM1ACVR1IRAK4IRAK1MAP4K3 | |
| SCHEMBL3716555 | 0.69 | NTRK1 (0.57) | PIM1IRAK4IRAK1MAP4K3PAK1 | |
| SCHEMBL3476130 | 0.69 | MAP4K3 (0.65) | MAP4K3METFLT3 | |
| SCHEMBL15431234 | 0.68 | IRAK4 (0.61) | PIM1IRAK4IRAK1CHRNB2CHRNA4 | |
| SCHEMBL3722850 | 0.67 | ALK (0.45) | ACVR1IRAK4ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343966-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-01-01 | — | — | US | disclosed |
| US-20090215776-A1 | Organic compounds | ADCOCK CLAIRE | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215776-A1 | Organic compounds | REN, RXFP1, MYLK | PIM1 3955/4885ACVR1 63/4885IRAK4 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.