Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | PTPRG | P23470 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185604 | 0.84 | ALDH1A1 (0.47) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL4637537 | 0.81 | ALDH1A1 (0.71) | KDM4EALDH1A1TDP1PTPRGLMNA | |
| SCHEMBL29441695 | 0.81 | KDM4E (0.75) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL17080193 | 0.81 | KDM4E (0.75) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL3381158 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL2032649 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1TDP1LMNAPOLB | |
| Bromide SCHEMBL10675654 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL3998999 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL3193541 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1TDP1LMNAPOLB | |
| SCHEMBL3195118 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1TDP1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2009-06-11 | — | — | US | disclosed |
| EP-1406881-B8 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | CAMH (CA) | 2006-10-25 | — | — | EP | disclosed |
| EP-1406881-B1 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | NEUROMOLECULAR INC (CA) | 2006-09-13 | — | — | EP | disclosed |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2006-07-27 | — | — | US | disclosed |
| EP-1593676-A1 | 8-Chloro-11-(4-(2'-hydroxyethyl)piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine of atypical anti-psychotic activity and having a low affinity for the dopamine D2 receptor | Neuromolecular, Inc. (CA) | 2005-11-09 | — | — | EP | disclosed |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ | 2005-10-06 | — | — | US | disclosed |
| US-6890919-B2 | Atypical antipsychotic agents having low affinity for the D2 receptor | KAPUR SHITIJ (CA) | 2005-05-10 | — | — | US | disclosed |
| EP-1406881-A1 | 11-PIPERAZINYLDIBENZO(B,F)(1,4)OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | Neuromolecular, Inc. (CA) | 2004-04-14 | — | — | EP | disclosed |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | NEUROMOLECULAR, INC. (CA) | 2003-07-17 | — | — | US | disclosed |
| WO-2003000670-A1 | A11-PIPERAZINYLDIBENZO (B, F) (1, 4) OXAZEPINES AND THIAZEPINES AS ATYPICAL ANTIPSYCHOTIC AGENTS HAVING LOW AFFINITY FOR THE D2 RECEPTOR | NEUROMOLECULAR, INC. (CA) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149442-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | KDM4E 4024/4885ALDH1A1 1345/4885TDP1 4461/4885 |
| US-20050222121-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | KDM4E 4024/4885ALDH1A1 1345/4885TDP1 4461/4885 |
| US-20060166965-A1 | Atypical antipsychotic agents having low affinity for the D2 receptor | DRD2, OPRD1, GRIN2A | KDM4E 4024/4885ALDH1A1 1345/4885TDP1 4461/4885 |
| US-20030135042-A1 | Atypical antipsychotic agents having low affinity for the D2 Receptor | OPRD1, HTR1A, DRD2 | KDM4E 4181/4885ALDH1A1 894/4885TDP1 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.