Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorhexidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorhexidine SCHEMBL2152457 | 0.99 | CNR1 (0.47) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL4250265 | 0.95 | SMN1; SMN2 (0.45) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL12044 | 0.94 | CNR1 (0.48) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL2975320 | 0.94 | CNR1 (0.48) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL2975314 | 0.94 | CNR1 (0.48) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL12043 | 0.94 | CNR1 (0.48) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL247291 | 0.94 | CNR1 (0.46) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL1550787 | 0.94 | LMNA (0.46) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| SCHEMBL6365499 | 0.94 | LMNA (0.46) | CNR1SLC6A3HDAC8ALDH1A1POLB | |
| Chlorhexidine SCHEMBL1551122 | 0.94 | LMNA (0.46) | CNR1SLC6A3HDAC8ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933147-B2 | Anti-microbial dental impression material | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-01-13 | — | — | US | claimed |
| US-11926805-B2 | Cleaning composition | THE PROCTER & GAMBLE COMPANY (US) | 2024-03-12 | — | — | US | disclosed |
| US-11866675-B2 | Cleaning composition | THE PROCTER & GAMBLE COMPANY (US) | 2024-01-09 | — | — | US | disclosed |
| WO-2024006631-A1 | ANTIMICROBIAL COMPOSITION COMPRISING A POLYIMIDE | THE PROCTER & GAMBLE COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |
| EP-4298906-A1 | ANTIMICROBIAL COMPOSITION COMPRISING A POLYIMIDE | The Procter & Gamble Company (US) | 2024-01-03 | — | — | EP | disclosed |
| US-20230413813-A1 | ANTIMICROBIAL COMPOSITION COMPRISING A POLYIMIDE | THE PROCTER & GAMBLE COMPANY | 2023-12-28 | — | — | US | disclosed |
| EP-3783089-B1 | ANTIMICROBIAL COMPOSITION COMPRISING ALKYLATED POLYVINYLPYRROLIDONE POLYMER | PROCTER & GAMBLE (US) | 2023-08-23 | — | — | EP | disclosed |
| US-11576379-B2 | Antimicrobial composition comprising alkylated polyvinylpyrrolidone polymer | THE PROCTER & GAMBLE COMPANY (US) | 2023-02-14 | — | — | US | disclosed |
| CN-114040677-A | Disinfectant composition | 宝洁公司 | 2022-02-11 | — | — | CN | disclosed |
| US-20210051957-A1 | ANTIMICROBIAL COMPOSITION COMPRISING ALKYLATED POLYVINYLPYRROLIDONE POLYMER | THE PROCTER & GAMBLE COMPANY | 2021-02-25 | — | — | US | disclosed |
| US-20210054306-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY | 2021-02-25 | — | — | US | disclosed |
| US-20210054307-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY | 2021-02-25 | — | — | US | disclosed |
| WO-2021035247-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2021-02-25 | — | — | WO | disclosed |
| WO-2021035250-A1 | ANTIMICROBIAL COMPOSITION COMPRISING ALKYLATED POLYVINYLPYRROLIDONE POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 2021-02-25 | — | — | WO | disclosed |
| EP-3783091-A1 | CLEANING COMPOSITION | The Procter & Gamble Company (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3783089-A1 | ANTIMICROBIAL COMPOSITION COMPRISING ALKYLATED POLYVINYLPYRROLIDONE POLYMER | The Procter & Gamble Company (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3783090-A1 | CLEANING COMPOSITION | The Procter & Gamble Company (US) | 2021-02-24 | — | — | EP | disclosed |
| US-8933147-B2 | Anti-microbial dental impression material | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20090047620-A1 | ANTI-MICROBIAL DENTAL IMPRESSION MATERIAL | 3M INNOVATIVE PROPERTIER COMPANY | 2009-02-19 | — | — | US | disclosed |
| EP-1787627-A1 | Anti-microbial dental impression material | 3M Innovative Properties Company (US) | 2007-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230413813-A1 | ANTIMICROBIAL COMPOSITION COMPRISING A POLYIMIDE | PUF60, PARG, CUTA | CNR1 4721/4885SLC6A3 4728/4885HDAC8 2581/4885 |
| US-20210051957-A1 | ANTIMICROBIAL COMPOSITION COMPRISING ALKYLATED POLYVINYLPYRROLIDONE POLYMER | PUF60, POLR1C, POLH | CNR1 3990/4885SLC6A3 3344/4885HDAC8 1755/4885 |
| US-11576379-B2 | Antimicrobial composition comprising alkylated polyvinylpyrrolidone polymer | PUF60, POLR1C, POLH | CNR1 3990/4885SLC6A3 3344/4885HDAC8 1755/4885 |
| US-20090047620-A1 | ANTI-MICROBIAL DENTAL IMPRESSION MATERIAL | CNDP2, POLL, AAAS | CNR1 2225/4885SLC6A3 4016/4885HDAC8 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.