Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260419 | 0.87 | PARK7 (0.51) | ALDH1A1AKR1B1AKR1A1PARK7PTGDR2 | |
| SCHEMBL4160449 | 0.82 | AKR1B1 (0.45) | AKR1B1AKR1A1PARK7PTGDR2 | |
| SCHEMBL4169552 | 0.81 | AKR1B1 (0.45) | AKR1B1AKR1A1PARK7PTGDR2 | |
| SCHEMBL4163964 | 0.81 | AKR1B1 (0.41) | AKR1B1AKR1A1GRIN1GRIN2BADAMTS5 | |
| SCHEMBL4259962 | 0.80 | AKR1A1 (0.50) | AKR1B1AKR1A1TP53GAAPTGDR2 | |
| SCHEMBL10955668 | 0.79 | AKR1B1 (0.47) | ALDH1A1AKR1B1AKR1A1PARK7CYP3A4 | |
| SCHEMBL4164986 | 0.78 | PARK7 (0.64) | ALDH1A1AKR1B1AKR1A1PARK7TP53 | |
| SCHEMBL4255745 | 0.78 | AKR1B1 (0.47) | AKR1B1AKR1A1PARK7TP53PTGDR2 | |
| SCHEMBL4161594 | 0.78 | AKR1B1 (0.42) | AKR1B1AKR1A1PARK7PTGDR2 | |
| SCHEMBL4262828 | 0.77 | AKR1B1 (0.46) | AKR1B1AKR1A1PARK7PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127412-B1 | IMIDAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1990-10-17 | — | — | EP | claimed |
| EP-0127412-A2 | Imidazolidinedione derivatives | PFIZER INC. (US) | 1984-12-05 | — | — | EP | claimed |
| US-20090076049-A1 | Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
| EP-0127412-B1 | IMIDAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4533667-A | FOR TREATMENT OF DIABETES | PFIZER INC. (US) | 1985-08-06 | — | — | US | disclosed |
| US-4533667-A | FOR TREATMENT OF DIABETES | PFIZER INC. (US) | 1985-08-06 | — | — | US | disclosed |
| EP-0127412-A2 | Imidazolidinedione derivatives | PFIZER INC. (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0127412-A2 | Imidazolidinedione derivatives | PFIZER INC. (US) | 1984-12-05 | — | — | EP | disclosed |
| US-4464380-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1984-08-07 | — | — | US | disclosed |
| US-4464380-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1984-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076049-A1 | Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 | TRPV1, TRPV5, TRPV2 | ALDH1A1 550/4885AKR1B1 344/4885AKR1A1 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.