Sugi Predict

Sugi Predict / Compounds / SCHEMBL4174764

SCHEMBL4174764

SCHEMBL4174764

C#Cc1cn([C@H]2C[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)c(=O)[nH]c1=O

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ RNASE1 P07998 1/20 0.46
▸ ABCG2 Q9UNQ0 3/20 0.41
▸ ABCB1 P08183 1/20 0.41
▸ TK1 P04183 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13413018 1.00 RNASE1 (0.46) RNASE1ABCG2ABCB1TK1
SCHEMBL9633257 0.90 RNASE1 (0.45) RNASE1ABCG2ABCB1
SCHEMBL4173873 0.89 RNASE1 (0.47) RNASE1ABCG2ABCB1
SCHEMBL4182321 0.89 RNASE1 (0.44) RNASE1ABCG2ABCB1
SCHEMBL5194272 0.89 RNASE1 (0.44) RNASE1ABCG2ABCB1
SCHEMBL22143533 0.89 RNASE1 (0.44) RNASE1ABCG2ABCB1
SCHEMBL22143473 0.87 RNASE1 (0.43) RNASE1ABCG2ABCB1
SCHEMBL9331381 0.87 TK1 (0.43) ABCG2ABCB1TK1
SCHEMBL9331388 0.87 TK1 (0.43) ABCG2ABCB1TK1
SCHEMBL12969271 0.87 RNASE1 (0.61) RNASE1ABCG2ABCB1TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4863906-A VIRICIDES, VARICELLA ZOSTER, CYTOMEGALOVIRUS BURROUGHS WELLCOME CO. (US) 1989-09-05 — — US claimed
US-20090004137-A1 Uridine Derivatives as Antiviral Drugs Against a Flaviviridae, Especially Hcv INSTITUTE NATIONAL DE LA SAINTE ET DE LA RECHDERCHE MEDICALE (FR) 2009-01-01 — — US disclosed
EP-1827457-A1 URIDINE DERIVATIVES AS ANTIVIRAL DRUGS AGAINST A FLAVIVIRIDAE, ESPECIALLY HCV INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2007-09-05 — — EP disclosed
WO-2006067606-A1 URIDINE DERIVATIVES AS ANTIVIRAL DRUGS AGAINST A FLAVIVIRIDAE, ESPECIALLY HCV INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2006-06-29 — — WO disclosed
EP-1674104-A1 Uridine derivatives as antiviral drugs against a flaviviridae, especially HCV INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2006-06-28 — — EP disclosed
US-5028596-A Varicella Zoster BURROUGHS WELLCOME CO. (US) 1991-07-02 — — US disclosed
EP-0208550-B1 ANTIVIRAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1991-05-22 — — EP disclosed
EP-0417560-A1 Antiviral compounds THE WELLCOME FOUNDATION LIMITED (GB) 1991-03-20 — — EP disclosed
US-4863906-A VIRICIDES, VARICELLA ZOSTER, CYTOMEGALOVIRUS BURROUGHS WELLCOME CO. (US) 1989-09-05 — — US disclosed
EP-0208550-A2 Antiviral compounds THE WELLCOME FOUNDATION LIMITED (GB) 1987-01-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090004137-A1 Uridine Derivatives as Antiviral Drugs Against a Flaviviridae, Especially Hcv NUDT1, UMPS, UPP1 RNASE1 255/4885ABCG2 302/4885ABCB1 958/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.