Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18812811 | 0.89 | CYP3A4 (0.61) | L3MBTL1MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2205957 | 0.87 | CASP6 (0.59) | MAPTKMT2AALK | |
| SCHEMBL13362096 | 0.87 | HTR1A (0.51) | L3MBTL1MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11294977 | 0.87 | CCR1 (0.46) | L3MBTL1MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1707770 | 0.87 | MAPT (0.57) | MAPTSMN1; SMN2ALDH1A1KMT2AALK | |
| SCHEMBL4170621 | 0.86 | MAPT (0.47) | L3MBTL1MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15358736 | 0.85 | ALDH1A1 (0.53) | L3MBTL1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL13362090 | 0.85 | MAPT (0.48) | L3MBTL1MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL13178104 | 0.84 | SIRT6 (0.52) | MAPTKMT2AALKCCR1MAPK1 | |
| SCHEMBL4171024 | 0.84 | CCR1 (0.51) | L3MBTL1MAPTSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061299-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |