SCHEMBL4175147

SCHEMBL4175147

COC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(C)cc1

nearest known ligand 0.73

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.73
RAB9A P51151 1/20 0.73
ATM Q13315 2/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
ALDH1A1 P00352 3/20 0.64
LMNA P02545 1/20 0.64
GLA P06280 1/20 0.64
CTSL P07711 3/20 0.60
THRB P10828 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
HSD17B10 Q99714 1/20 0.58
POLB P06746 1/20 0.56
PTPN1 P18031 1/20 0.54
LNPEP Q9UIQ6 1/20 0.54
CTSS P25774 1/20 0.53
CTSK P43235 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26820570 1.00 GAA (0.73) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL31206887 0.91 GAA (0.76) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL2461492 0.91 GAA (0.76) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL1793176 0.91 GAA (0.76) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL16305947 0.90 GAA (0.60) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL4364442 0.89 TSHR (0.62) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL4360846 0.89 TSHR (0.62) GAARAB9AATML3MBTL1ALDH1A1
SCHEMBL13885677 0.89 GAA (0.73) GAARAB9AATMALDH1A1LMNA
SCHEMBL25496384 0.88 RAB9A (0.79) GAARAB9AATMALDH1A1LMNA
SCHEMBL8726251 0.88 GAA (0.64) GAARAB9AATML3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250024871-A1 AMIDE COMPOUNDS AND THEIR USE AS FLAVOR MODIFIERS FIRMENICH INCORPORATED (US) 2025-01-23 US disclosed
WO-2023091315-A2 AMIDE COMPOUNDS AND THEIR USE AS FLAVOR MODIFIERS FIRMENICH INCORPORATED (US) 2023-05-25 WO disclosed
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers DEWIS MARK L 2009-02-19 US disclosed
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers DEWIS MARK L 2009-02-19 US disclosed
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers DEWIS MARK L 2009-02-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers TAS2R10, TAS2R50, TAS2R8 GAA 104/4885RAB9A 1204/4885ATM 1831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.