Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162437 | 0.84 | PTPN7 (0.54) | SCN9APDE3BPDE3AP2RY12SCN10A | |
| SCHEMBL21200606 | 0.83 | LCK (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21865489 | 0.83 | KDM4E (0.43) | SCN9ASCN10AKDM4ENPC1RAB9A | |
| SCHEMBL18940463 | 0.80 | MAPK1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7342388 | 0.78 | HDAC8 (0.55) | KDM4EALDH1A1MAPT | |
| SCHEMBL629635 | 0.77 | SMN1; SMN2 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5697665 | 0.76 | PTPN7 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21865487 | 0.76 | MEN1 (0.57) | CYSLTR1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL23733198 | 0.75 | LMNA (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23413042 | 0.74 | CYSLTR2 (0.47) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197914-A1 | Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197914-A1 | Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them | CCR3, CCR1, CCR4 | SCN9A 2221/4885PDE3B 61/4885PDE3A 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.