Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ADH1B | P00325 | 4/20 | 0.41 |
| ▸ | ADH1A | P07327 | 4/20 | 0.41 |
| ▸ | ADH7 | P40394 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ADH1C | P00326 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ADH4 | P08319 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3307433 | 0.75 | ADH1B (0.46) | ALDH1A1ADH1BADH1AADH7ADH1C | |
| SCHEMBL13715429 | 0.75 | ALDH1A1 (0.60) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL9453310 | 0.73 | ALDH1A1 (0.58) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL21118113 | 0.72 | ALDH1A1 (0.62) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL7355629 | 0.70 | ALDH1A1 (0.67) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL5114807 | 0.70 | ALDH1A1 (0.60) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL4614428 | 0.70 | ALDH1A1 (0.67) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL4614425 | 0.70 | ALDH1A1 (0.60) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL11033708 | 0.70 | ALDH1A1 (1.00) | ALDH1A1LMNAHTTCA1CA2 | |
| SCHEMBL3759352 | 0.70 | ALDH1A1 (0.60) | ALDH1A1LMNAHTTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | TGFBR1, TGFBR2, SMAD3 | ALDH1A1 163/4885ADH1B 3772/4885ADH1A 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.