Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 6/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4177755 | 0.81 | ALDH1A1 (0.40) | NQO2MCHR1MEN1KMT2ANPC1 | |
| SCHEMBL13737587 | 0.79 | RAB9A (0.52) | NQO2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL20873730 | 0.79 | ALDH1A1 (0.46) | NQO2MCHR1MEN1KMT2ANPC1 | |
| SCHEMBL14567654 | 0.79 | MCHR1 (0.37) | NQO2MCHR1ALDH1A1TDP2NSD2 | |
| SCHEMBL6970068 | 0.79 | MCHR1 (0.37) | NQO2MCHR1NPC1RAB9AALDH1A1 | |
| SCHEMBL4180685 | 0.78 | NQO2 (0.49) | NQO2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4173484 | 0.78 | MCHR1 (0.36) | NQO2MCHR1MEN1KMT2ANPC1 | |
| SCHEMBL38652759 | 0.77 | NQO2 (0.45) | NQO2MEN1KMT2AALDH1A1ALOX5AP | |
| SCHEMBL28942691 | 0.75 | ALOX5AP (0.35) | MCHR1ALDH1A1ALOX5APFEN1TDP2 | |
| SCHEMBL21631384 | 0.74 | BACE1 (0.36) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183379-B2 | Antitumor agents | WAYNE STATE UNIVERSITY (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183379-B2 | Antitumor agents | WAYNE STATE UNIVERSITY (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183379-B2 | Antitumor agents | WAYNE STATE UNIVERSITY (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090069372-A1 | ANTITUMOR AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
| US-20090069372-A1 | ANTITUMOR AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
| US-20090069372-A1 | ANTITUMOR AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
| US-7470788-B2 | Antitumor agents | WAYNE STATE UNIVERSITY (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470788-B2 | Antitumor agents | WAYNE STATE UNIVERSITY (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470788-B2 | Antitumor agents | WAYNE STATE UNIVERSITY (US) | 2008-12-30 | — | — | US | disclosed |
| CN-101258129-A | Quinoline derivatives and use as antitumor agents | UNIV WAYNE STATE (US) | 2008-09-03 | — | — | CN | disclosed |
| EP-1940794-A2 | QUINOLINE DERIVATIVES AND USE AS ANTITUMOR AGENTS | WAYNE STATE UNIVERSITY (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030780-A2 | QUINOLINE DERIVATIVES AND USE AS ANTITUMOR AGENTS | WAYNE STATE UNIVERSITY (US) | 2007-03-15 | — | — | WO | disclosed |
| US-20070060612-A1 | Antitumor agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-15 | — | — | US | disclosed |
| US-20070060612-A1 | Antitumor agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-15 | — | — | US | disclosed |
| US-20070060612-A1 | Antitumor agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-15 | — | — | US | disclosed |
| US-20070054938-A1 | Antitumor agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-08 | — | — | US | disclosed |
| US-20070054938-A1 | Antitumor agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-08 | — | — | US | disclosed |
| US-20070054938-A1 | Antitumor agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060612-A1 | Antitumor agents | TP53, NHERF1, MCL1 | NQO2 448/4885MCHR1 2616/4885MEN1 38/4885 |
| US-20090069372-A1 | ANTITUMOR AGENTS | NHERF1, BACH1, MCL1 | NQO2 294/4885MCHR1 2868/4885MEN1 76/4885 |
| US-20070054938-A1 | Antitumor agents | TP53, NHERF1, MCL1 | NQO2 448/4885MCHR1 2616/4885MEN1 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.