Sugi Predict

Sugi Predict / Compounds / SCHEMBL417954

SCHEMBL417954

SCHEMBL417954

CCOC(=O)c1cc(-c2cc(F)cc(Cl)c2)c(-c2ccc(F)c(Cl)c2)o1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 6/20 0.40
▸ MAOB P27338 1/20 0.40
▸ XPO1 O14980 1/20 0.39
▸ PTPRC P08575 1/20 0.39
▸ PTPN2 P17706 1/20 0.39
▸ PTPN1 P18031 1/20 0.39
▸ PTPA Q15257 1/20 0.39
▸ RPA1 P27694 1/20 0.39
▸ HSD17B10 Q99714 2/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ APP P05067 1/20 0.38
▸ TARBP2 Q15633 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ HDAC3 O15379 1/20 0.35
▸ HDAC1 Q13547 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL418491 0.89 PGR (0.41) ALOX5MAOBPTPRCPTPN2PTPN1
SCHEMBL2484122 0.83 XPO1 (0.36) ALOX5XPO1PTPRCPTPN2PTPN1
SCHEMBL417818 0.83 RPA1 (0.53) RPA1NPC1RAB9AAPPALDH1A1
SCHEMBL419840 0.82 FNTA (0.42) ALOX5MAOBXPO1POLBALDH1A1
SCHEMBL418485 0.81 MAOB (0.44) ALOX5MAOBPTPRCPTPN2PTPN1
SCHEMBL419322 0.80 XPO1 (0.43) ALOX5MAOBXPO1HSD17B10NPC1
SCHEMBL420126 0.79 ALOX5 (0.45) ALOX5MAOBL3MBTL1ALDH1A1
SCHEMBL419611 0.78 ALOX5 (0.47) ALOX5MAOBHSD17B10NPC1POLB
SCHEMBL421473 0.77 ALOX5 (0.56) ALOX5MAOBHSD17B10NPC1POLB
SCHEMBL2486902 0.76 RPA1 (0.41) RPA1APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376479-B1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO KG (DE) 2016-03-02 — — EP disclosed
US-8324268-B2 Substituted furancarboxamides, and use thereof AICURIS GMBH & CO. KG (DE) 2012-12-04 — — US disclosed
US-8324268-B2 Substituted furancarboxamides, and use thereof AICURIS GMBH & CO. KG (DE) 2012-12-04 — — US disclosed
US-8324268-B2 Substituted furancarboxamides, and use thereof AICURIS GMBH & CO. KG (DE) 2012-12-04 — — US disclosed
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 — — US disclosed
WO-2010075957-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120022059-A1 SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF AADAC, DDC, TPMT ALOX5 948/4885MAOB 272/4885XPO1 3828/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.