Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10845107 | 1.00 | CYP2D6 (0.71) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL8984444 | 1.00 | CYP2D6 (0.71) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL10845287 | 1.00 | CYP2D6 (0.71) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL29630319 | 1.00 | CYP2D6 (0.71) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL10845109 | 1.00 | CYP2D6 (0.71) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL8317770 | 1.00 | CYP2D6 (0.71) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL2723896 | 0.90 | CYP2D6 (0.75) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL10846857 | 0.90 | CYP2D6 (0.75) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL10846851 | 0.90 | CYP2D6 (0.75) | CYP2D6TSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL10843818 | 0.90 | CYP2D6 (0.75) | CYP2D6TSHRMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303148-B | 1-substituted beta-carboline derivatives and application thereof | 南京农业大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-111303148-A | 1-substituted β -carboline derivatives and application thereof | 南京农业大学 | 2020-06-19 | — | — | CN | disclosed |
| US-8772311-B2 | Harmine derivatives, intermediates used in their preparations, preparation processes and use thereof | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD. (CN) | 2014-07-08 | — | — | US | disclosed |
| US-8772311-B2 | Harmine derivatives, intermediates used in their preparations, preparation processes and use thereof | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD. (CN) | 2014-07-08 | — | — | US | disclosed |
| US-20090227619-A1 | Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD. (CN) | 2009-09-10 | — | — | US | disclosed |
| EP-1634881-A1 | HARMINE DERIVATIVES, INTERMEDIATES USED IN THEIR PREPARATION, PREPARATION PROCESSES AND USE THEREOF | Xinjiang Huashidan Pharmaceutical Research Co., Ltd. (CN) | 2006-03-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227619-A1 | Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo | TPH1, HTR1F, TPH2 | CYP2D6 173/4885TSHR 739/4885MAPK1 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.