⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11568727 | 0.72 | — | — | |
| SCHEMBL7627621 | 0.57 | TRPA1 (0.37) | — | |
| SCHEMBL6407543 | 0.52 | — | — | |
| SCHEMBL29394860 | 0.46 | TRPA1 (0.32) | — | |
| SCHEMBL30218263 | 0.46 | TRPA1 (0.32) | — | |
| SCHEMBL2398838 | 0.46 | CYP19A1 (0.30) | — | |
| SCHEMBL5144501 | 0.43 | — | — | |
| SCHEMBL5081705 | 0.42 | — | — | |
| SCHEMBL5081702 | 0.42 | — | — | |
| SCHEMBL5084742 | 0.42 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | claimed |
| US-20090221560-A1 | Pharmaceutical Formulation | ACTAVIS GROUP PTC EHF | 2009-09-03 | — | — | US | disclosed |
| US-7498433-B2 | Process and intermediates for the preparation of olanzapine | KRKA, TOVARNA ZDRAVIL, D.D. (SI) | 2009-03-03 | — | — | US | disclosed |
| EP-1594879-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF OLANZAPINE | KRKA TOVARNA ZDRAVIL D D NOVO (SI) | 2008-10-22 | — | — | EP | disclosed |
| US-20060040921-A1 | Process and intermediates for the preparation of olanzapine | KRKA, TOVARNA ZDRAVIL D.D. (SI) | 2006-02-23 | — | — | US | disclosed |
| EP-0685233-B1 | Thieno[1,5]benzodiazepine for treating gastrointestinal conditions | LILLY CO ELI (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0685233-A3 | Thieno[1,5]benzodiazepine for treating gastrointestinal conditions. | LILLY CO ELI (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0685233-A2 | Thieno[1,5]benzodiazepine for treating gastrointestinal conditions | ELI LILLY AND COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5457101-A | For gastrointestinal disorders; irritable bowel syndrome | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |