Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 4/20 | 0.37 |
| ▸ | RXRB | P28702 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065491 | 0.94 | PDE4D (0.41) | PDE4DPDE5APDE1APDE1BPDE7A | |
| SCHEMBL4183985 | 0.88 | ALDH1A1 (0.40) | SLC6A4SLC6A3OPRD1ALDH1A1L3MBTL1 | |
| SCHEMBL2065311 | 0.82 | ALDH1A1 (0.40) | SLC6A4SLC6A3OPRD1ALDH1A1L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL4185040 | 0.81 | DPP4 (0.37) | PDE4DPDE5APDE1APDE1BPDE7A | |
| SCHEMBL1092157 | 0.79 | PDE4D (0.32) | PDE4DPDE5APDE1APDE1BPDE7A | |
| SCHEMBL3908761 | 0.73 | CDK9 (0.36) | PDE4DPDE5APDE1APDE1BPDE7A | |
| SCHEMBL4067647 | 0.72 | POLB (0.37) | PDE4DPDE5APDE1APDE1BPDE7A | |
| SCHEMBL1092228 | 0.70 | PDE4A (0.33) | PDE4DRXRARXRBPDE4APDE4B | |
| SCHEMBL1094081 | 0.70 | PDE4A (0.33) | PDE4DRXRARXRBPDE4APDE4B | |
| SCHEMBL4207175 | 0.70 | PDE5A (0.39) | PDE4DPDE5APDE1APDE1BPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021337-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127726-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |