Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065311 | 0.94 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4181004 | 0.88 | PDE4D (0.39) | ALDH1A1L3MBTL1SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL1092147 | 0.82 | PSD (0.35) | ALDH1A1L3MBTL1OPRD1CHKAHPGD | |
| SCHEMBL2065491 | 0.82 | PDE4D (0.41) | ALDH1A1L3MBTL1SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL208481 | 0.77 | SLC6A3 (0.41) | ALDH1A1L3MBTL1SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4179157 | 0.77 | LIPC (0.38) | — | |
| SCHEMBL3902228 | 0.75 | CDK9 (0.40) | ALDH1A1L3MBTL1SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL1093033 | 0.73 | PSD (0.34) | ALDH1A1L3MBTL1OPRD1CHKAPSD | |
| SCHEMBL1092157 | 0.72 | PDE4D (0.32) | PSDMAP2K4 | |
| SCHEMBL207570 | 0.70 | MAP2K4 (0.35) | ALDH1A1L3MBTL1SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021337-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127726-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |