Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.31 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818004 | 0.88 | UCHL1 (0.39) | BRD4UCHL1PIK3CDPIK3R2PIK3CA | |
| SCHEMBL3820974 | 0.88 | UCHL1 (0.39) | UCHL1FFAR2PIK3CDPIK3R2PIK3CA | |
| SCHEMBL3817877 | 0.87 | UCHL1 (0.40) | BRD4UCHL1GPR84FFAR2 | |
| SCHEMBL3811906 | 0.87 | BRD4 (0.41) | BRD4UCHL1 | |
| SCHEMBL3817108 | 0.87 | UCHL1 (0.40) | BRD4UCHL1GPR84 | |
| SCHEMBL3815242 | 0.86 | BRD4 (0.42) | BRD4UCHL1FFAR2 | |
| SCHEMBL4557563 | 0.82 | DRD1 (0.31) | — | |
| SCHEMBL4464614 | 0.78 | ALDH1A1 (0.34) | NPSR1TRPC3TRPC6 | |
| SCHEMBL1010230 | 0.77 | GRM5 (0.44) | UCHL1 | |
| SCHEMBL1013247 | 0.77 | GRM5 (0.41) | UCHL1CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |