SCHEMBL4181784

SCHEMBL4181784

O=C(Cc1nnn[nH]1)N1CCOCC1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.43
TSHR P16473 2/20 0.43
ALOX15 P16050 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MAPT P10636 2/20 0.42
KMT2A Q03164 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
LMNA P02545 2/20 0.42
ALDH1A1 P00352 2/20 0.42
FKBP1A P62942 1/20 0.40
POLB P06746 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
AKT1 P31749 1/20 0.39
THRB P10828 1/20 0.39
HTT P42858 1/20 0.39
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15756703 0.83 CACNA1H (0.41) GAATSHRKMT2ALMNAALDH1A1
SCHEMBL3555078 0.83 ALDH1A1 (0.33) TSHRLMNAALDH1A1SMN1; SMN2
SCHEMBL13741175 0.78 HRH3 (0.39) TSHRL3MBTL1LMNAALDH1A1TP53
SCHEMBL3667811 0.76 GFER (0.49) GAAMAPTKMT2ALMNAALDH1A1
SCHEMBL4168114 0.75 RBP4 (0.51) GAATSHRALOX15HSD17B10MAPT
SCHEMBL3809883 0.74 KMT2A (0.43) HSD17B10MAPTKMT2AALDH1A1POLB
SCHEMBL12582728 0.73 ALDH1A1 (0.49) KMT2ALMNAALDH1A1POLBSMN1; SMN2
SCHEMBL4982004 0.71 HPGD (0.43) GAAALOX15HSD17B10MAPTKMT2A
SCHEMBL5969160 0.70 MAPT (0.43) HSD17B10MAPTKMT2AL3MBTL1LMNA
SCHEMBL8705221 0.69 KDM4E (0.40) GAAHSD17B10MAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US claimed
EP-1912980-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION Wockhardt Limited (IN) 2008-04-23 EP claimed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation POLL, POLM, POLRMT GAA 1145/4885TSHR 3584/4885ALOX15 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.