Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194198 | 0.92 | HRH3 (1.00) | HRH3ALDH1A1MAPTGAANPSR1 | |
| SCHEMBL4188505 | 0.89 | HRH3 (0.84) | HRH3ALDH1A1NPSR1LMNATSHR | |
| SCHEMBL4186008 | 0.87 | HRH3 (0.84) | HRH3ALDH1A1MAPTGAANPSR1 | |
| SCHEMBL4182903 | 0.84 | HRH3 (0.80) | HRH3ALDH1A1MAPTGAANPSR1 | |
| SCHEMBL4188339 | 0.84 | HRH3 (0.85) | HRH3ALDH1A1NPSR1TSHRSMN1; SMN2 | |
| SCHEMBL4176012 | 0.84 | HRH3 (0.85) | HRH3ALDH1A1NPSR1TSHR | |
| SCHEMBL4019371 | 0.80 | ALDH1A1 (0.84) | HRH3ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL4024863 | 0.80 | HRH3 (1.00) | HRH3ALDH1A1NPSR1LMNATSHR | |
| SCHEMBL4475308 | 0.75 | HRH3 (0.84) | HRH3 | |
| SCHEMBL4184767 | 0.75 | HRH3 (1.00) | HRH3ALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | claimed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |