Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194198 | 0.91 | HRH3 (1.00) | HRH3NPSR1ALDH1A1MAPTGAA | |
| SCHEMBL4182903 | 0.90 | HRH3 (0.80) | HRH3NPSR1ALDH1A1MAPTGAA | |
| SCHEMBL4182572 | 0.87 | HRH3 (0.84) | HRH3NPSR1ALDH1A1MAPTGAA | |
| SCHEMBL4019371 | 0.80 | ALDH1A1 (0.84) | HRH3NPSR1ALDH1A1MAPTHTT | |
| SCHEMBL4024863 | 0.79 | HRH3 (1.00) | HRH3NPSR1ALDH1A1SLC1A3TSHR | |
| SCHEMBL29761985 | 0.75 | SLC1A3 (1.00) | HRH3NPSR1ALDH1A1HTTSLC1A3 | |
| SCHEMBL4188505 | 0.75 | HRH3 (0.84) | HRH3NPSR1ALDH1A1SLC1A3TSHR | |
| SCHEMBL4018816 | 0.74 | HRH3 (1.00) | HRH3 | |
| SCHEMBL4184767 | 0.74 | HRH3 (1.00) | HRH3NPSR1ALDH1A1TSHR | |
| SCHEMBL4020046 | 0.73 | HRH3 (1.00) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | claimed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |