Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4182769 | 1.00 | POLB (0.40) | POLBSMN1; SMN2TSHRMAPK1LMNA | |
| SCHEMBL4178078 | 0.88 | CTSL (0.41) | POLBSMN1; SMN2TSHRMAPK1LMNA | |
| SCHEMBL4178660 | 0.87 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2TSHRMAPK1LMNA | |
| SCHEMBL4181430 | 0.85 | ACLY (0.42) | POLBSMN1; SMN2TSHRMAPK1LMNA | |
| SCHEMBL4180985 | 0.84 | TRPV4 (0.46) | POLBKMT2AMEN1ALDH1A1ACLY | |
| SCHEMBL4188294 | 0.83 | CTSS (0.44) | POLBSMN1; SMN2TSHRMAPK1KMT2A | |
| SCHEMBL4175732 | 0.82 | KMT2A (0.41) | POLBTSHRLMNAKMT2AMEN1 | |
| SCHEMBL4175731 | 0.82 | KMT2A (0.41) | POLBTSHRLMNAKMT2AMEN1 | |
| SCHEMBL4182779 | 0.77 | CCR1 (0.49) | POLBTSHRLMNAKMT2AMEN1 | |
| SCHEMBL4180614 | 0.77 | KMT2A (0.45) | SMN1; SMN2TSHRMAPK1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124619-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124619-A1 | NOVEL COMPOUNDS | TRPV4, TRPC4, TRPV1 | POLB 4819/4885SMN1; SMN2 3714/4885TSHR 1343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.