SCHEMBL4183457

SCHEMBL4183457

O=c1ccc(C#Cc2ccc(Oc3ccc(C#Cc4ccc(=O)oc4)cc3)cc2)co1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTRC Q99895 1/20 0.34
FFAR1 O14842 3/20 0.33
APP P05067 2/20 0.33
GAA P10253 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ACACB O00763 4/20 0.33
GRM5 P41594 1/20 0.33
PARP15 Q460N3 1/20 0.33
PARP10 Q53GL7 1/20 0.33
PARP2 Q9UGN5 1/20 0.33
HAO1 Q9UJM8 5/20 0.32
ACACA Q13085 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
MAPK1 P28482 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13567260 0.92 APP (0.37) CTRCFFAR1APPGAASMN1; SMN2
SCHEMBL6002092 0.74 CTRC (0.63) CTRCGAASMN1; SMN2PARP15PARP10
SCHEMBL5161481 0.70
SCHEMBL4190833 0.69
SCHEMBL6287635 0.68 LTA4H (0.63) FFAR1APPACACBGRM5MAPT
SCHEMBL3839253 0.68 APP (0.63) FFAR1APPACACBGRM5HAO1
SCHEMBL13569207 0.67 CTRC (0.53) CTRCAPPGAASMN1; SMN2
SCHEMBL14380094 0.66 LTA4H (0.60) FFAR1APPACACBGRM5HAO1
SCHEMBL6727043 0.66 LTA4H (0.60) FFAR1APPACACBGRM5HAO1
SCHEMBL9999906 0.66 TEAD4 (0.56) FFAR1APPSMN1; SMN2GRM5MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476416-B1 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES LLC (US) 2015-12-30 EP disclosed
EP-1476416-B1 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES LLC (US) 2015-12-30 EP disclosed
US-7635741-B2 Curable polyacetylenes used as dielectrics in making microelectronics such as integrated circuits DOW GLOBAL TECHNOLOGIES INC. 2009-12-22 US disclosed
US-7635741-B2 Curable polyacetylenes used as dielectrics in making microelectronics such as integrated circuits DOW GLOBAL TECHNOLOGIES INC. 2009-12-22 US disclosed
US-20040053033-A1 Multifunctional monomers and their use in making cross-linked polymers and porous films NIU Q JASON (US) 2004-03-18 US disclosed