Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 7/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185003 | 0.88 | PDE5A (0.34) | HRH3 | |
| SCHEMBL4196923 | 0.88 | HPGD (0.42) | HRH3 | |
| SCHEMBL884195 | 0.87 | SPR (0.35) | SPRNAMPTHRH3HTR2B | |
| SCHEMBL4189000 | 0.86 | HRH3 (0.34) | SPRNAMPTHRH3 | |
| SCHEMBL4194920 | 0.85 | CYP2C9 (0.35) | SPRHRH3HTR2B | |
| SCHEMBL4192427 | 0.79 | JAK2 (0.33) | HRH3MGLL | |
| SCHEMBL4188991 | 0.79 | ALDH1A1 (0.36) | SPRNAMPTHRH3 | |
| SCHEMBL883906 | 0.78 | HRH3 (0.38) | HRH3HTR2BMGLL | |
| SCHEMBL1092071 | 0.78 | HTR2B (0.37) | SPRNAMPTHRH3HTR2BMGLL | |
| SCHEMBL1092073 | 0.78 | HTR2B (0.37) | SPRNAMPTHRH3HTR2BMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | claimed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | claimed |
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |