Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 6/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4179209 | 0.86 | CHRM2 (0.34) | KCNH2HRH3SPRCHRM2PIK3CA | |
| SCHEMBL4183670 | 0.85 | SPR (0.34) | HTR2BHRH3SPR | |
| SCHEMBL1093152 | 0.80 | PIK3CA (0.37) | CYP2C9CYP2C19HTR2BMAPK14KCNH2 | |
| SCHEMBL1093150 | 0.80 | PIK3CA (0.37) | CYP2C9CYP2C19HTR2BMAPK14KCNH2 | |
| SCHEMBL4192427 | 0.74 | JAK2 (0.33) | KCNH2HRH3LMNASMN1; SMN2NPSR1 | |
| SCHEMBL884195 | 0.74 | SPR (0.35) | HTR2BHRH3SPR | |
| SCHEMBL4185003 | 0.73 | PDE5A (0.34) | HRH3LMNASMN1; SMN2NPSR1 | |
| SCHEMBL4196923 | 0.73 | HPGD (0.42) | HRH3CHRM2NPSR1 | |
| SCHEMBL1092603 | 0.72 | CHRM2 (0.37) | SPRCHRM2PIK3CAMTORLMNA | |
| SCHEMBL1092608 | 0.72 | CHRM2 (0.37) | SPRCHRM2PIK3CAMTORLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |