Isoproterenol

Isoproterenol

SCHEMBL41841

CC(C)NCC(O)c1ccc(O)c(O)c1.O=S(=O)(O)O

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1ADRB2ADRB3

The experimentally established mechanism targets of Isoproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 known ✓ P07550 6/20 0.85
ADRB1 known ✓ P08588 4/20 0.85
ADRB3 known ✓ P13945 4/20 0.85
MAPT P10636 7/20 0.85
TDP1 Q9NUW8 6/20 0.85
KDM4E B2RXH2 6/20 0.85
MEN1 O00255 5/20 0.85
KMT2A Q03164 5/20 0.85
TSHR P16473 4/20 0.85
MAPK1 P28482 4/20 0.85
HSD17B10 Q99714 4/20 0.85
MTOR P42345 3/20 0.85
LMNA P02545 3/20 0.85
CYP1A2 P05177 3/20 0.85
CYP3A4 P08684 3/20 0.85
HIF1A Q16665 3/20 0.85
NFKB1 P19838 2/20 0.85
ALDH1A1 P00352 2/20 0.85
ADORA3 P0DMS8 2/20 0.85
DRD2 P14416 2/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoproterenol SCHEMBL5682034 0.98 MAPT (0.82) MAPTADRB2TDP1KDM4EMEN1
Isoproterenol SCHEMBL7268328 0.97 ADRB2 (0.85) MAPTADRB2TDP1KDM4EMEN1
Isoproterenol SCHEMBL582812 0.95 ADRB2 (0.85) MAPTADRB2TDP1KDM4EMEN1
Metaproterenol SCHEMBL9051746 0.93 BLM (0.79) MAPTADRB2TDP1KDM4EMEN1
Isoproterenol SCHEMBL29519146 0.92 MAPT (1.00) MAPTADRB2TDP1KDM4EMEN1
Isoproterenol SCHEMBL29386243 0.92 MAPT (1.00) MAPTADRB2TDP1KDM4EMEN1
Levisoprenaline SCHEMBL250806 0.92 MAPT (1.00) MAPTADRB2TDP1KDM4EMEN1
Levisoprenaline SCHEMBL29620666 0.92 MAPT (1.00) MAPTADRB2TDP1KDM4EMEN1
Isoproterenol SCHEMBL4166 0.92 MAPT (1.00) MAPTADRB2TDP1KDM4EMEN1
Isoproterenol SCHEMBL4165 0.92 MAPT (1.00) MAPTADRB2TDP1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1796 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114053206-A Medicinal floating preparation and preparation method thereof 常州恒邦药业有限公司 2022-02-18 CN claimed
CN-114053207-A Sustained-release pharmaceutical composition and preparation method thereof 常州恒邦药业有限公司 2022-02-18 CN claimed
US-20220008334-A1 GASTRIC RETENTIVE DEVICES CLEXIO BIOSCIENCES LTD. (IL) 2022-01-13 US claimed
US-11147766-B2 Gastric retentive devices CLEXIO BIOSCIENCES LTD. (IL) 2021-10-19 US claimed
WO-2018087779-A1 TRANSDERMAL DELIVERY SYSTEM AND SPRAY-DEVICE CIPLA LIMITED (IN) 2018-05-17 WO claimed
CN-107382750-A A kind of preparation method of isoproterenol sulfate 山东科源制药股份有限公司 2017-11-24 CN claimed
CN-107011187-A A kind of preparation method of isoproterenol sulfate dihydrate 山东科源制药股份有限公司 2017-08-04 CN claimed
US-9649093-B2 Cavity-filling biopsy site markers SENORX, INC. (US) 2017-05-16 US claimed
US-20160120510-A1 CAVITY-FILLING BIOPSY SITE MARKERS SENORX, INC. 2016-05-05 US claimed
US-7500479-B2 Aerosol generators and methods for producing aerosols PHILIP MORRIS USA INC. (US) 2009-03-10 US claimed
EP-0455463-B1 Packaging for microdoses of powdered medicament for inhalation RIKER LABORATORIES INC (US) 1994-12-07 EP claimed
EP-0536204-B1 THE USE OF SOLUBLE FLUOROSURFACTANTS FOR THE PREPARATION OF METERED-DOSE AEROSOL FORMULATIONS MINNESOTA MINING & MFG (US) 1994-04-06 EP claimed
EP-0536204-A1 THE USE OF SOLUBLE FLUOROSURFACTANTS FOR THE PREPARATION OF METERED-DOSE AEROSOL FORMULATIONS. MINNESOTA MINING & MFG (US) 1993-04-14 EP claimed
US-5192548-A DEVICE RIKER LABORATOIRES, INC. (US) 1993-03-09 US claimed
WO-1992000062-A1 THE USE OF SOLUBLE FLUOROSURFACTANTS FOR THE PREPARATION OF METERED-DOSE AEROSOL FORMULATIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-01-09 WO claimed
EP-0455463-A1 Packaging for microdoses of powdered medicament for inhalation RIKER LABORATORIES, INC. (US) 1991-11-06 EP claimed
US-5023088-A Drug delivery dispenser ALZA CORPORATION (US) 1991-06-11 US claimed
EP-0145209-B1 A KIT OR DEVICE AND METHOD FOR ADMINISTERING GANGLIOSIDES AND DERIVATIVES THEREOF OF INHALATION AND PHARMACEUTICAL COMPOSITIONS SUITABLE THEREFOR FIDIA S.p.A. (IT) 1989-10-11 EP claimed
US-4352789-A COATING OF PERFLUORINATED SURFACTANT; INHALANTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1982-10-05 US claimed
US-4038417-A ADRENERGIC STIMULATING AGENTS, ISOPROTERENOL NELSON RESEARCH & DEVELOPMENT COMPANY (US) 1977-07-26 US claimed