Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metaproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.74 |
| ▸ | BLM | P54132 | 5/20 | 0.79 |
| ▸ | MEN1 | O00255 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 4/20 | 0.79 |
| ▸ | APEX1 | P27695 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.74 |
| ▸ | TSHR | P16473 | 5/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.74 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.74 |
| ▸ | MTOR | P42345 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoproterenol SCHEMBL41841 | 0.93 | MAPT (0.85) | BLMMEN1KMT2ALMNAAPEX1 | |
| Metaproterenol SCHEMBL3841247 | 0.93 | ADRB2 (0.85) | BLMMEN1KMT2ALMNAAPEX1 | |
| Isoproterenol SCHEMBL5682034 | 0.92 | MAPT (0.82) | BLMMEN1KMT2ALMNAAPEX1 | |
| Terbutaline SCHEMBL8761821 | 0.91 | BLM (0.67) | BLMMEN1KMT2ALMNAAPEX1 | |
| Isoproterenol SCHEMBL7268328 | 0.90 | ADRB2 (0.85) | BLMMEN1KMT2ALMNAAPEX1 | |
| Isoproterenol SCHEMBL582812 | 0.89 | ADRB2 (0.85) | BLMMEN1KMT2ALMNAAPEX1 | |
| Metaproterenol SCHEMBL3049439 | 0.89 | MEN1 (1.00) | BLMMEN1KMT2ALMNAAPEX1 | |
| Metaproterenol SCHEMBL9614523 | 0.89 | MEN1 (1.00) | BLMMEN1KMT2ALMNAAPEX1 | |
| Metaproterenol SCHEMBL41816 | 0.89 | MEN1 (1.00) | BLMMEN1KMT2ALMNAAPEX1 | |
| Metaproterenol SCHEMBL41815 | 0.89 | MEN1 (1.00) | BLMMEN1KMT2ALMNAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034600-A1 | BETA-AGONISTS AS AN AID TO MAINTAIN OR ENHANCE STRENGTH AND ENDURANCE | UNIVERSITY OF NEW MEXICO (US) | 1996-11-07 | — | — | WO | claimed |
| WO-1996034600-A1 | BETA-AGONISTS AS AN AID TO MAINTAIN OR ENHANCE STRENGTH AND ENDURANCE | UNIVERSITY OF NEW MEXICO (US) | 1996-11-07 | — | — | WO | disclosed |