Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyproheptadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.93 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | SETD7 | Q8WTS6 | 7/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.93 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.93 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.93 |
| ▸ | HTR1A | P08908 | 4/20 | 0.93 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.93 |
| ▸ | DRD1 | P21728 | 4/20 | 0.93 |
| ▸ | DRD3 | P35462 | 4/20 | 0.93 |
| ▸ | HTR2A | P28223 | 4/20 | 0.93 |
| ▸ | HTR2C | P28335 | 4/20 | 0.93 |
| ▸ | HTR2B | P41595 | 4/20 | 0.93 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.93 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyproheptadine SCHEMBL9934753 | 1.00 | LMNA (0.97) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL30772122 | 0.98 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL29380652 | 0.98 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL20610743 | 0.98 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL5500354 | 0.98 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL41842 | 0.98 | LMNA (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL7923153 | 0.96 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL4021 | 0.96 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL29369949 | 0.96 | SETD7 (1.00) | LMNAMEN1MAPTPMP22KMT2A | |
| Cyproheptadine SCHEMBL28514693 | 0.95 | SETD7 (0.90) | LMNAMEN1MAPTPMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118319853-A | Pharmaceutical composition containing cyproheptadine hydrochloride and preparation method thereof | 安徽杰玺医药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-105025897-B | Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2 (1H) -one derivatives having both β 2 adrenergic receptor agonist and M3 muscarinic receptor antagonist activity | 阿尔米雷尔有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-103554263-B | Apoptotic anti-IgE antibodies in conjunction with the IgE that film combines | 健泰科生物技术公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-101390830-B | Anarexol cream and preparation method thereof | CHANGZHOU NO 4 PHARMACEUTICAL FACTORY CO LTD | 2011-05-18 | — | — | CN | disclosed |
| CN-101390830-A | Anarexol cream and preparation method thereof | CHANGZHOU NO 4 PHARMACEUTICAL (CN) | 2009-03-25 | — | — | CN | disclosed |