Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | BCL2 | P10415 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.54 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026265 | 0.92 | KMT2A (0.59) | KCNH2DRD3SLC6A3CHRM2ADRA2A | |
| SCHEMBL3860853 | 0.80 | OPRM1 (0.51) | KCNH2DRD3SLC6A3CHRM2ADRA2A | |
| SCHEMBL16769444 | 0.79 | KMT2A (0.82) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 | |
| SCHEMBL13309468 | 0.79 | KMT2A (0.82) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 | |
| SCHEMBL5026280 | 0.78 | HRH3 (0.44) | KCNH2CHRM1HRH3CYP2D6ALDH1A1 | |
| SCHEMBL13686427 | 0.78 | KCNH2 (0.69) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 | |
| SCHEMBL7668121 | 0.78 | CHRM2 (0.83) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 | |
| SCHEMBL4032844 | 0.74 | KCNH2 (0.71) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 | |
| Chlorcyclizine SCHEMBL12157065 | 0.73 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 | |
| SCHEMBL16769329 | 0.73 | KCNH2 (0.76) | KCNH2SLC6A2SLC6A4DRD3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2019676-A2 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | Neuromed Pharmaceuticals, Ltd. (CA) | 2009-02-04 | — | — | EP | claimed |
| WO-2007133481-A2 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-11-22 | — | — | WO | claimed |