Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026265 | 0.86 | KMT2A (0.59) | OPRM1OPRD1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4185164 | 0.80 | KCNH2 (0.57) | OPRM1OPRK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5026280 | 0.76 | HRH3 (0.44) | KMT2AALDH1A1CYP2D6CHRM1KCNH2 | |
| SCHEMBL5027779 | 0.72 | CACNA2D1 (0.73) | CACNA1ACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL13597052 | 0.67 | OPRM1 (0.50) | OPRM1OPRD1OPRK1OPRL1SLC6A9 | |
| Cyclizine SCHEMBL5656056 | 0.66 | CYP2D6 (0.82) | OPRM1OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL27404587 | 0.65 | MAOB (0.50) | OPRM1OPRD1OPRK1OPRL1KMT2A | |
| SCHEMBL4669298 | 0.65 | OPRM1 (0.58) | OPRM1OPRD1OPRK1OPRL1KMT2A | |
| SCHEMBL5027734 | 0.64 | USP2 (0.50) | KMT2AMEN1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL9327563 | 0.64 | ALDH1A1 (0.71) | KMT2AMEN1ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670775-A4 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-04-22 | — | — | EP | claimed |
| JP-2007504174-A | — | — | 2007-03-01 | — | — | JP | claimed |
| EP-1670775-A1 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-06-21 | — | — | EP | claimed |
| WO-2005021523-A1 | PIPERAZINE SUBSTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED TECHNOLOGIES, INC. (CA) | 2005-03-10 | — | — | WO | claimed |