Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185164 | 0.92 | KCNH2 (0.57) | KMT2AMEN1CYP2D6CHRM2ADRA2A | |
| SCHEMBL3860853 | 0.86 | OPRM1 (0.51) | KMT2AMEN1CYP2D6MAOBCHRM2 | |
| SCHEMBL5026280 | 0.85 | HRH3 (0.44) | KMT2ACYP2D6CHRM1KCNH2ALDH1A1 | |
| SCHEMBL4669298 | 0.76 | OPRM1 (0.58) | KMT2AMEN1CYP2D6MAOBCHRM2 | |
| Cyclizine SCHEMBL5656056 | 0.74 | CYP2D6 (0.82) | KMT2AMEN1CYP2D6MAOBCHRM2 | |
| SCHEMBL13994872 | 0.74 | KMT2A (1.00) | KMT2AMEN1CYP2D6MAOBALDH1A1 | |
| SCHEMBL13900792 | 0.74 | OPRM1 (0.63) | KMT2AMEN1CYP2D6MAOBCHRM2 | |
| SCHEMBL3919536 | 0.73 | OPRM1 (0.78) | KMT2AMEN1CYP2D6MAOBCHRM2 | |
| SCHEMBL8175607 | 0.73 | OPRM1 (0.78) | KMT2AMEN1CYP2D6MAOBCHRM2 | |
| SCHEMBL7977689 | 0.73 | OPRM1 (0.78) | KMT2AMEN1CYP2D6MAOBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | claimed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | claimed |
| WO-2022216953-A1 | COMPOUNDS FOR USE IN INCREASING FOXG1 EXPRESSION | BELIEVE IN A CURE, INC. (US) | 2022-10-13 | — | — | WO | disclosed |
| EP-2654726-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | Zalicus Pharmaceuticals Ltd. (CA) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012122274-A1 | SELF-EMULSIFYING FORMULATIONS AND METHODS OF USE THEREOF | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012122279-A1 | SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-13 | — | — | WO | disclosed |
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |